What is the adequate PRP dose for an effective treatment? An in vitro experimental study on the skin

dc.authorid0000-0001-9077-2976en_US
dc.authorid0000-0003-2710-9615en_US
dc.authorid0000-0003-1705-9781en_US
dc.contributor.authorGörgü, Metin
dc.contributor.authorGökkaya, Ali
dc.contributor.authorKaranfil, Ertuğrul
dc.date.accessioned2023-06-02T10:56:36Z
dc.date.available2023-06-02T10:56:36Z
dc.date.issued2021en_US
dc.departmentBAİBÜ, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümüen_US
dc.description.abstractBackground: The clinical results of many studies on platelet-rich plasma (PRP) differ due to a lack of standardization in PRP preparation and administration as well as many variables such as PRP preparation methods, platelet concentration, and platelet activation. Objectives: The authors sought to investigate a different variable that will affect PRP application results. How much PRP should be injected into the unit area of tissue for an effective PRP treatment? Methods: The study was performed on fresh surplus tissues of 20 patients that were discarded in abdominoplasty and mammoplasty operations. Nine areas of 4 cm(2) were marked on the skin. Fluorescein-stained PRP was injected intradermally with 3 different gauge needles at 3 different doses (0.01, 0.03, and 0.05 mL). After injections, spreads of the fluorescent dye-covered areas in horizontal and vertical planes were measured and compared. For the horizontal plane measurements, the dye spread was measured first from the surface of the skin and second from the dermal surface of the skin. In addition, the width and depth of the dye spread in the dermis were measured from vertical sections. Results: Changing the needle diameter does not affect the width or depth (thickness) of the PRP spread in the dermis. Increasing the applied dose to 0.03 mL increases the spread to the width and depth (thickness). Conclusions: In research evaluating the effectiveness of PRP treatments, it is necessary to report the volume of PRP to be applied per unit of tissue.en_US
dc.identifier.citationGörgü, M., Gökkaya, A., & Karanfil, E. (2021). What is the adequate PRP dose for an effective treatment? An in vitro experimental study on the skin. Aesthetic surgery journal, 41(7), NP887-NP901.en_US
dc.identifier.doi10.1093/asj/sjab043
dc.identifier.endpageNP901en_US
dc.identifier.issn1090-820X
dc.identifier.issn1527-330X
dc.identifier.issue7en_US
dc.identifier.pmid33493280en_US
dc.identifier.scopus2-s2.0-85106270444en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpageNP887en_US
dc.identifier.urihttp://dx.doi.org/10.1093/asj/sjab043
dc.identifier.urihttps://hdl.handle.net/20.500.12491/11054
dc.identifier.volume41en_US
dc.identifier.wosWOS:000670780100025en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorGörgü, Metin
dc.institutionauthorGökkaya, Ali
dc.institutionauthorKaranfil, Ertuğrul
dc.language.isoenen_US
dc.publisherOxford Univ Press Incen_US
dc.relation.ispartofAesthetic Surgery Journalen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectPlatelet-Rich-Plasmaen_US
dc.subjectFacial Rejuvenationen_US
dc.titleWhat is the adequate PRP dose for an effective treatment? An in vitro experimental study on the skinen_US
dc.typeArticleen_US

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