The use of reference change values in clinical laboratories

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dc.authorid0000-0002-4060-3354en_US
dc.contributor.authorBuğdaycı, Güler
dc.contributor.authorOğuzman, Hamdi
dc.contributor.authorArattan, Havva Yasemin
dc.contributor.authorŞaşmaz, Guler
dc.date.accessioned2021-06-23T19:42:33Z
dc.date.available2021-06-23T19:42:33Z
dc.date.issued2015
dc.departmentBAİBÜ, Tıp Fakültesi, Temel Tıp Bilimleri Bölümüen_US
dc.description.abstractBackground: The use of Reference Change Values (RCV) has been advocated as very useful for monitoring individuals. Most of these are performed for monitoring individuals in acute situations and for following up the improvement or deterioration of chronic diseases. In our study, we aimed at evaluating the RCV calculation for 24 clinical chemistry analytes widely used in clinical laboratories and the utilization of this data. Methods: Twenty-four serum samples were analyzed with Abbott kits (Abbott Laboratories, Abbott Park, IL, USA), manufactured for use with the Architect c8000 (R) (Abbott Laboratories, Abbott Park, IL, USA) auto-analyzer. We calculated RCV using the following formula: RCV = Z x 2(1/2)x (CVA2 + CVw2)(1/2).d Four reference change values (RCV) were calculated for each analyte using four statistical probabilities (0.95, and 0.99, unidirectional and bidirectional). Moreover, by providing an interval after identifying upper and lower limits with the Reference Change Factor (RCF), serially measured tests were calculated by using two formulas: exp (Z x 2(1/2) (CVA2 + CVw(2))(1/2)/100) for RCFUP and (1/RCFUP) for RCFDOWN. Results: RCVs of these analytes were calculated as 14.63% for glucose, 29.88% for urea, 17.75% for ALP, 53.39% for CK, 46.98% for CK-MB, 21.00% amylase, 8.00% for total protein, 8.70% for albumin, 51.08% for total bilirubin, 86.34% for direct bilirubin, 6.40% for calcium, 15.03% for creatinine, 21.47% for urate, 14.19% for total cholesterol, 46.62% for triglyceride, 20.51% for HDL-cholesterol, 29.59% for AST, 46.31% for ALT, 31.54% for GGT, 20.92% for LDH, 19.75% for inorganic phosphate, 3.05% for sodium, 11.75% for potassium, 4.44% for chloride (RCV, p < 0.05, unidirectionally). Conclusions: We suggest using RCV as well as using population-based reference intervals in clinical laboratories. RCV could be available as a tool for making clinical decision, especially when monitoring individuals.en_US
dc.identifier.doi10.7754/Clin.Lab.2014.140906
dc.identifier.endpage257en_US
dc.identifier.issn1433-6510
dc.identifier.issue3-4en_US
dc.identifier.pmid25974990en_US
dc.identifier.scopus2-s2.0-84929411754en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage251en_US
dc.identifier.urihttps://doi.org/10.7754/Clin.Lab.2014.140906
dc.identifier.urihttps://hdl.handle.net/20.500.12491/8527
dc.identifier.volume61en_US
dc.identifier.wosWOS:000353008800006en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorBuğdaycı, Güler
dc.institutionauthorOğuzman, Hamdi
dc.institutionauthorArattan, Havva Yasemin
dc.language.isoenen_US
dc.publisherClin Lab Publen_US
dc.relation.ispartofClinical Laboratoryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectReference Valuesen_US
dc.subjectAnalytical Chemistry Methodsen_US
dc.subjectData Interpretationen_US
dc.subjectStatisticalen_US
dc.titleThe use of reference change values in clinical laboratoriesen_US
dc.typeArticleen_US

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