Effect of age on rabbit bladder function and structure following partial outlet obstruction

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dc.authorid0000-0002-2577-8711
dc.contributor.authorAğartan, Canan Aldırmaz
dc.contributor.authorWhitbeck, Catherine
dc.contributor.authorChichester, Paul
dc.contributor.authorKogan, Barry A.
dc.contributor.authorLevin, Robert M.
dc.date.accessioned2021-06-23T19:18:29Z
dc.date.available2021-06-23T19:18:29Z
dc.date.issued2005
dc.departmentBAİBÜ, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümüen_US
dc.description.abstractPurpose: We determined whether young and old rabbits respond differently to partial bladder outlet obstruction. Materials and Methods: A total of 16 male New Zealand White rabbits were separated into 2 groups of 8 each. Group 1 consisted of young rabbits (age 7 weeks) and group 2 consisted of old rabbits (age 2 years). Four rabbits per group underwent partial outlet obstructions and 4 underwent sham operation. Four weeks following surgery individual bladder strips were used for contractile studies and the remaining tissue was examined histologically. Results: Contractile responses to all forms of stimulation between the young and old sham operated groups were similar. Contractile responses to all forms of stimulation were significantly decreased to the same degree in the 2 obstructed groups. However, the rate of tension generation to field stimulation was decreased to a significantly greater degree in young vs old bladders. Although young and old bladders showed smooth muscle hypertrophy, older rabbits showed significantly greater thickening of the serosa than young rabbits. Young rabbits showed significant inflammation, hemorrhage and expansion of the lamina propria, whereas old rabbits showed none of these characteristics. Conclusions: Although there were only minor differences in the physiological response of young and old bladders to obstruction, young rabbits showed a significantly greater degree of histological damage. This may have been due to the thinner wall and greater sensitivity to distention.en_US
dc.identifier.doi10.1097/01.ju.0000149033.92717.93
dc.identifier.endpage1405en_US
dc.identifier.issn0022-5347
dc.identifier.issn1527-3792
dc.identifier.issue4en_US
dc.identifier.pmid15758813en_US
dc.identifier.scopus2-s2.0-15044342487en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage1400en_US
dc.identifier.urihttps://doi.org/10.1097/01.ju.0000149033.92717.93
dc.identifier.urihttps://hdl.handle.net/20.500.12491/5739
dc.identifier.volume173en_US
dc.identifier.wosWOS:000227687600069en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorAğartan, Canan Aldırmaz
dc.language.isoenen_US
dc.publisherLippincott Williams & Wilkinsen_US
dc.relation.ispartofJournal Of Urologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectBladderen_US
dc.subjectBladder Neck Obstructionen_US
dc.subjectRabbitsen_US
dc.titleEffect of age on rabbit bladder function and structure following partial outlet obstructionen_US
dc.typeArticleen_US

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