Poorly controlled hypertension is associated with elevated serum uric acid to HDL-cholesterol ratio: A cross-sectional cohort study

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dc.authorid0000-0001-7306-5233en_US
dc.authorid0000-0003-2712-5930en_US
dc.authorid0000-0002-4162-5563en_US
dc.authorid0000-0002-3836-2125en_US
dc.authorid0000-0003-2811-0052en_US
dc.authorid0000-0003-4201-9757en_US
dc.authorid0000-0003-2399-9585en_US
dc.authorid0000-0003-3817-851Xen_US
dc.contributor.authorAktaş, Gülali
dc.contributor.authorKhalid, Atiqa
dc.contributor.authorKurtkulağı, Özge
dc.contributor.authorDuman, Tuba Taslamacıoğlu
dc.contributor.authorBilgin, Satılmış
dc.contributor.authorKahveci, Gizem
dc.contributor.authorTel, Burçin Meryem Atak
dc.contributor.authorSincer, İsa
dc.contributor.authorGüneş, Yılmaz
dc.date.accessioned2024-02-16T13:28:06Z
dc.date.available2024-02-16T13:28:06Z
dc.date.issued2022en_US
dc.departmentBAİBÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.description.abstractObjectives The diagnosis and follow-up of hypertension (HT) depend on the blood pressure measurements, which can be affected by several factors. In the present work, we aimed to explore the role of uric acid/HDL-cholesterol ratio (UHR) in HT and whether/or not it was associated with poor blood pressure control. Methods In this retrospective cross-sectional cohort study, all the participants treated for hypertension and then followed up in the internal medicine clinics of our institution were enrolled. Hypertensive patients were grouped as either poorly or well-controlled hypertension groups, according to the suggestions of Joint National Committee VIII criteria and healthy volunteers were enrolled as control group. UHR of the study groups was compared. Results Our study cohort consisted of 535 subjects; 258 in the well-controlled HT group, 186 in the poorly controlled HT group, and 91 in the control group. Median UHR levels of the poorly controlled HT group (13 (4-43) %) were significantly higher than well-controlled HT group 11 (4-22) %) and control group (8 (4-19) %) (p < 0.001). UHR was correlated with systolic (r = 0.33, p < 0.001) and diastolic (r = 0.28, p < 0.001) BP. UHR level greater than 11% has 70% sensitivity and 60% specificity in predicting poor BP control (AUC: 0.73, p < 0.001, 95%CI: 0.68-0.77). UHR was an independent risk factor for poor BP control in HT subjects and a unit elevation in UHR increased the risk of poorer BP control by 7.3 times (p < 0.001, 95%CI: 3.9-13.63). Conclusion Assessment of UHR may be useful in HT patients since elevated UHR levels could be associated with poor blood pressure control in this population.en_US
dc.identifier.citationAktas, G., Khalid, A., Kurtkulagi, O., Duman, T. T., Bilgin, S., Kahveci, G., ... & Gunes, Y. (2022). Poorly controlled hypertension is associated with elevated serum uric acid to HDL-cholesterol ratio: a cross-sectional cohort study. Postgraduate Medicine, 134(3), 297-302.en_US
dc.identifier.doi10.1080/00325481.2022.2039007
dc.identifier.endpage302en_US
dc.identifier.issn0032-5481
dc.identifier.issn1941-9260
dc.identifier.issue3en_US
dc.identifier.pmid35142235en_US
dc.identifier.scopus2-s2.0-85125241124en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage297en_US
dc.identifier.urihttp://dx.doi.org/10.1080/00325481.2022.2039007
dc.identifier.urihttps://hdl.handle.net/20.500.12491/12031
dc.identifier.volume134en_US
dc.identifier.wosWOS:000754942000001en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorAktaş, Gülali
dc.institutionauthorDuman, Tuba Taslamacıoğlu
dc.institutionauthorBilgin, Satılmış
dc.institutionauthorSincer, İsa
dc.institutionauthorGüneş, Yılmaz
dc.language.isoenen_US
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofPostgraduate Medicineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectUric Acid to HDL Ratioen_US
dc.subjectHypertensionen_US
dc.subjectFollow-Upen_US
dc.subjectBlood Pressureen_US
dc.subjectEndothelial Dysfunctionen_US
dc.subjectİnflammationen_US
dc.titlePoorly controlled hypertension is associated with elevated serum uric acid to HDL-cholesterol ratio: A cross-sectional cohort studyen_US
dc.typeArticleen_US

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