Long-term outcome of kidney transplantation from elderly living and expanded criteria deceased donors

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dc.authorid0000-0002-2886-1166en_US
dc.authorid0000-0001-5582-6430
dc.authorid0000-0002-6542-3923
dc.authorid0000-0003-2466-2618
dc.contributor.authorTanrısev, Mehmet
dc.contributor.authorHoşcoşkun, Cüneyt
dc.contributor.authorAşçı, Gülay
dc.contributor.authorSözbilen, Murat
dc.contributor.authorFırat, Özgür
dc.contributor.authorErtilav, Muhittin
dc.date.accessioned2021-06-23T19:42:15Z
dc.date.available2021-06-23T19:42:15Z
dc.date.issued2015
dc.departmentBAİBÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.description.abstractThe imbalance between organ demand and supply causes the increasing use of suboptimal donors. The aim of this study is to investigate the survival and allograft function of kidney transplantation from standard (SLD) and elderly living (ELD), standard criteria (SCDD) and expanded criteria deceased (ECDD) donors. All patients transplanted from 1997 to 2005 were investigated according to the donor characteristics. Data were collected retrospectively during the 83.4 +/- 43.1 months of follow-up period. ELD was defined as donor age >= 60 years. ECDD was defined as UNOS criteria. A total of 458 patients were divided into four groups: SLD (n:191), ELD (n:67), SCDD (n:154), and ECDD (n:46). Seven-year death-censored graft survival in SLD, ELD, SCDD, and ECDD were 81.6%, 64.8%, 84.7%, and 68.3%, respectively (p = 0.003). The death-censored graft survival in ELD group was lower than in SLD (p = 0.007) and SCDD (p = 0.007) groups, while in ECDD group it was lower than in SCDD group (p = 0.026). Patient survival was similar. In ECDD group, 83% of total deaths occurred within the first 3 years, mainly due to infections (66.6%) (p < 0.05). Estimated glomerular filtration rate (eGFR) was lower in ELD (compared with SLD and SCDD); and ECDD (compared with SCDD) at last visit. In multivariate analysis, ELD, experience of an acute rejection episode and presence of delayed graft function were the independent predictors for death censored graft loss. Transplantation of a suboptimal kidney provides inferior graft survival and function. A higher number of deaths due to infection in the early post-transplant period in the ECDD group are noteworthy.en_US
dc.identifier.doi10.3109/0886022X.2014.982488
dc.identifier.endpage253en_US
dc.identifier.issn0886-022X
dc.identifier.issn1525-6049
dc.identifier.issue2en_US
dc.identifier.pmid25470081en_US
dc.identifier.scopus2-s2.0-84923199126en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage249en_US
dc.identifier.urihttps://doi.org/10.3109/0886022X.2014.982488
dc.identifier.urihttps://hdl.handle.net/20.500.12491/8417
dc.identifier.volume37en_US
dc.identifier.wosWOS:000350554300014en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorErtilav, Muhittin
dc.language.isoenen_US
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofRenal Failureen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectElderly Donoren_US
dc.subjectExpanded Criteria Donoren_US
dc.subjectKidney Transplantationen_US
dc.subjectSurvivalen_US
dc.titleLong-term outcome of kidney transplantation from elderly living and expanded criteria deceased donorsen_US
dc.typeArticleen_US

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