Hematological and biochemical parameters as diagnostic and prognosticmarkers in SARS-COV-2 infected patients of Pakistan: A retrospective comparative analysis

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dc.authorid0000-0003-1022-967Xen_US
dc.authorid0000-0003-4257-5825en_US
dc.authorid0000-0003-2712-5930en_US
dc.authorid0000-0003-3365-0707en_US
dc.authorid0000-0003-3474-000Xen_US
dc.authorid0000-0001-7306-5233en_US
dc.contributor.authorKhalid, Atiqa
dc.contributor.authorJaffar, Muhammad Ali
dc.contributor.authorKhan, Tabinda
dc.contributor.authorLail, Raees Abbas
dc.contributor.authorAli, Sana
dc.contributor.authorAktaş, Gülali
dc.date.accessioned2023-06-22T11:52:45Z
dc.date.available2023-06-22T11:52:45Z
dc.date.issued2021en_US
dc.departmentBAİBÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.description.abstractObjectives:This study was conducted to investigate alteration in blood parameters and theirassociation with the presence, severity, and mortality of COVID-19 patients as the data onhematological abnormalities associated with the Pakistani COVID-19 patients is limited.Methodology:A double-centered, hospital-based comparative retrospective case study wasconducted, to include all the admitted patients (n= 317) having COVID-19 Polymerase chainreaction (PCR) positive. The control group (n= 157) tested negative for COVID-19.Results:Of 317 admitted cases, the majority were malesn= 198 (62.5%). Associatedcomorbidities, lower lymphocytes, platelets, and higher White blood cells, neutrophil,neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) were found inCOVID-19 cases as compared to healthy controls (p< 0.001 for all). The biochemicalparameters of cases including Ferritin, D-Dimer, CRP, IL-6, LDH, ALT, AST, and APTT alsoshowed a statistically significant difference compared with standard values (p< 0.001 forall). However, their comparison with a severity level of the severe and non-severe groupsshowed significance for WBCs, neutrophils, NLR (p< 0.001 for all), and PLR (p= 0.06) only.Receiver operating characteristic curve analysis showed that NLR had the highest area undercurve (0.84) followed by 1/lymphocyte (0.82), neutrophils (0.74), PLR (0.67),1/platelets (0.68)and WBC’s (0.65). Comparison of cases and controls with recommended cut-offvaluesderived from sensitivity and 1-specificity was also done (p< 0.001).Conclusion:Monitoring all the hematological and biochemical parameters including novelhemograms NLR, PLR can aid clinicians to identify potentially severe cases at early stagesand initiate effective management in time which may reduce the overall mortality of COVID-19 patients.Abbreviations: ALT, Alanine Aminotransferase; APTT, Activated Partial Thromboplastin Time;AST, Aspartate Aminotransferase; CBCs, complete blood counts; COVID-19, coronavirusdisease 2019; CRP, C-Reactive Protein; GRA, granulocytes; HGB, hemoglobin; LDH, Lactatedehydrogenase; Lymph, lymphocyte; MLR, Monocyte to Lymphocyte ratio.; NLR, Neutrophilto Lymphocyte ratio; PLR, Platelet to lymphocyte ratio; PLTs, platelets count; PT,Prothrombin time; RBCs, red blood cells; SARS-CoV-2, Severe acute respiratory syndromecoronavirus 2; WBCs, white blood cellsen_US
dc.identifier.citationKhalid, A., Ali Jaffar, M., Khan, T., Abbas Lail, R., Ali, S., Aktas, G., ... & Muhammad, N. (2021). Hematological and biochemical parameters as diagnostic and prognostic markers in SARS-COV-2 infected patients of Pakistan: a retrospective comparative analysis. Hematology, 26(1), 529-542.en_US
dc.identifier.doi10.1080/16078454.2021.1950898
dc.identifier.endpage542en_US
dc.identifier.issn1024-5332
dc.identifier.issn1607-8454
dc.identifier.issue1en_US
dc.identifier.pmid34334100en_US
dc.identifier.scopus2-s2.0-85111870719en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage529en_US
dc.identifier.urihttp://dx.doi.org/10.1080/16078454.2021.1950898
dc.identifier.urihttps://hdl.handle.net/20.500.12491/11186
dc.identifier.volume26en_US
dc.identifier.wosWOS:000679958300001en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorAktaş, Gülali
dc.language.isoenen_US
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofHematologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectCOVID-19 SARS-CoV-2en_US
dc.subjectBiomarkersen_US
dc.subjectHematological Parametersen_US
dc.subjectLymphocyte Ratioen_US
dc.subjectCoronavirus Diseaseen_US
dc.subjectRisk-Factorsen_US
dc.titleHematological and biochemical parameters as diagnostic and prognosticmarkers in SARS-COV-2 infected patients of Pakistan: A retrospective comparative analysisen_US
dc.typeArticleen_US

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