Contribution of fragmented QRS on myocardial perfusion imaging in the assessment of functionally significant coronary artery stenoses

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dc.authorid0000-0003-1719-599
dc.contributor.authorÇalışkan, Billur
dc.contributor.authorKorkmaz, Ayşe Nurdan
dc.contributor.authorErdem, Fatma
dc.date.accessioned2021-06-23T19:43:39Z
dc.date.available2021-06-23T19:43:39Z
dc.date.issued2016
dc.departmentBAİBÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.description.abstractOBJECTIVE: The evaluation of the functional significance of coronary artery stenosis is of great clinical importance in patient management or for decisions concerning coronary intervention. Recently, fragmented QRS (fQRS) on electrocardiography (ECG) has been introduced as a predictor of myocardial scarring as well as myocardial ischaemia in coronary artery disease. We aimed to investigate any additive value of fQRS to myocardial perfusion SPECT in evaluating the functional significance of the intermediate degree of coronary stenosis. PATIENTS AND METHODS: Patients who were referred for myocardial perfusion imaging (MPI) to evaluate the functional significance of intermediate (40-70%) coronary artery stenosis were analyzed retrospectively; 102 patients were included in the study. ECG records were evaluated to detect fQRS. MPI was interpreted visually and semiquantitatively by two nuclear medicine physicians blinded to the electro-cardiographic findings. Summed stress scores (SSS), summed rest scores and summed difference scores (SDS) were calculated according to the 17-segment model. RESULTS: The mean age of the patients was 62.56 +/- 9.5 years, and 64 were males (62.7%). Ischaemia was detected in 30 patients, and the frequency of fQRS was significantly higher in patients with ischaemia than in patients with normal perfusion (54.8% vs. 23.8%, respectively; p<0.001). Myocardial scarring was detected in 15 patients, 7 of whom had coexistent myocardial ischaemia. fQRS was positively correlated with the SSS (r=374, p=0.001), SDS (r=0.460, p=0.001) and summed motion score (r=0.228, p=0.024). fQRS was an independent predictor of myocardial ischemia in multivariate analyses (OR=11.181; CI=3.900-32.057; p<0.001). CONCLUSIONS: The presence of fQRS on ECG is associated with myocardial ischaemia in patients who had an intermediate degree of coronary stenosis.en_US
dc.identifier.endpage1581en_US
dc.identifier.issn1128-3602
dc.identifier.issue8en_US
dc.identifier.pmid27160131en_US
dc.identifier.scopus2-s2.0-85017173804en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage1575en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12491/8823
dc.identifier.urihttps://www.webofscience.com/wos/woscc/full-record/WOS:000380260000021
dc.identifier.urihttps://pubmed.ncbi.nlm.nih.gov/27160131/
dc.identifier.urihttps://www.europeanreview.org/article/10678
dc.identifier.volume20en_US
dc.identifier.wosWOS:000380260000021en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorÇalışkan, Billur
dc.institutionauthorKorkmaz, Ayşe Nurdan
dc.institutionauthorErdem, Fatma
dc.language.isoenen_US
dc.publisherVerduci Publisheren_US
dc.relation.ispartofEuropean Review For Medical And Pharmacological Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectFragmented QRSen_US
dc.subjectMyocardial Perfusion SPECTen_US
dc.subjectIschaemiaen_US
dc.subjectFunctional Significanceen_US
dc.subjectCoronary Artery Stenosisen_US
dc.titleContribution of fragmented QRS on myocardial perfusion imaging in the assessment of functionally significant coronary artery stenosesen_US
dc.typeArticleen_US

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