Serum retinol-binding protein 4, leptin, and plasma asymmetric dimethylarginine levels in obese and nonobese young women with polycystic ovary syndrome

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dc.authorid0000-0002-4060-3354en_US
dc.authorid0000-0002-7251-6853
dc.authorid0000-0003-3031-1646
dc.contributor.authorYıldızhan, Recep
dc.contributor.authorİlhan, Gökçe Anık
dc.contributor.authorYıldızhan, Begüm
dc.contributor.authorKolusarı, Ali
dc.contributor.authorAdalı, Ertan
dc.contributor.authorBuğdaycı, Güler
dc.date.accessioned2021-06-23T19:27:58Z
dc.date.available2021-06-23T19:27:58Z
dc.date.issued2011
dc.departmentBAİBÜ, Tıp Fakültesi, Temel Tıp Bilimleri Bölümüen_US
dc.description.abstractObjective: To evaluate retinol-binding protein 4 (RBP4), leptin, and asymmetric dimethylarginine (ADMA) levels in young women with polycystic ovary syndrome (PCOS) and to investigate their relationship with each other and with clinical, metabolic, and hormonal parameters. Design: Clinical study. Setting: University hospital. Patient(s): Fifty-seven young women with PCOS (obese [n = 27] and nonobese [n = 30]) and 27 age-matched healthy controls. Intervention(s): History and physical examination, peripheral venous blood sampling. Main Outcome Measure(s): Asymmetric dimethylarginine, RBP4, leptin, LH, FSH, DHEAS, total T, E-2, total cholesterol, high-density lipoprotein (HDL) cholesterol, low-density lipoprotein (LDL) cholesterol, triglyceride (TG), and homeostasis model assessment insulin resistance index (HOMA-IR). Result(s): Obese women with PCOS had significantly higher HOMA-IR, DHEAS, leptin, RBP4, and ADMA levels. Leptin levels were significantly increased in nonobese subjects with PCOS. Leptin and ADMA levels were positively correlated with HOMA-IR in PCOS. There was no correlation between RBP4 and HOMA-IR. Leptin, RBP4, and ADMA levels are positively correlated in PCOS. Conclusion(s): [1] Young obese women with PCOS have increased ADMA, RBP4, and leptin levels, and they are positively correlated with each other. [2] The increased levels of leptin are independent of obesity, and leptin seems to have an association with IR. [3] Levels of RBP4 may not reflect IR in PCOS. (Fertil Steril (R) 2011;96:246-50. (C) 2011 by American Society for Reproductive Medicine.)en_US
dc.identifier.doi10.1016/j.fertnstert.2011.04.073
dc.identifier.endpage250en_US
dc.identifier.issn0015-0282
dc.identifier.issn1556-5653
dc.identifier.issue1en_US
dc.identifier.pmid21600576en_US
dc.identifier.scopus2-s2.0-79959869560en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage246en_US
dc.identifier.urihttps://doi.org/10.1016/j.fertnstert.2011.04.073
dc.identifier.urihttps://hdl.handle.net/20.500.12491/6926
dc.identifier.volume96en_US
dc.identifier.wosWOS:000292283000066en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorBuğdaycı, Güler
dc.language.isoenen_US
dc.publisherElsevier Science Incen_US
dc.relation.ispartofFertility And Sterilityen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectPCOSen_US
dc.subjectleptinen_US
dc.subjectADMAen_US
dc.subjectRBP4en_US
dc.subjectInsulin Resistance (HOMA-IR)en_US
dc.subjectObeseen_US
dc.subjectNonobeseen_US
dc.titleSerum retinol-binding protein 4, leptin, and plasma asymmetric dimethylarginine levels in obese and nonobese young women with polycystic ovary syndromeen_US
dc.typeArticleen_US

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