Presynaptic inhibition in restless legs syndrome

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dc.authorid0000-0002-1845-0902en_US
dc.authorid0000-0003-2183-7080en_US
dc.authorid0000-0001-8616-832Xen_US
dc.authorid0000-0002-9647-4432
dc.contributor.authorTürkoğlu, Şule Aydın
dc.contributor.authorBolaç, Elif Sultan
dc.contributor.authorYıldız, Serpil
dc.contributor.authorKalaycıoğlu, Oya
dc.contributor.authorYıldız, Nebil
dc.date.accessioned2021-06-23T19:55:17Z
dc.date.available2021-06-23T19:55:17Z
dc.date.issued2021
dc.departmentBAİBÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.description.abstractIntroduction: Restless legs syndrome (RLS) is a condition that particularly urges at night in resting and causes the need to move the legs. Although the pathophysiology has not yet been clarified, dopamine and iron metabolism and spinal cord pathologies are blamed for causing the condition. There are few studies on spinal reflex mechanisms on RLS. In the present study, we aimed to investigate the role of presynaptic inhibition (PreI) in the spinal cord in RLS. Methods: Fourteen patients with RLS and 14 controls with similar demographic characteristics were included in the study. Soleus muscle H-reflex (Ht) investigation was performed for subjects whose electrophysiologic investigation was normal. The Ht response was conditioned to the stimulation of the common peroneal nerve (CPN) (Hc). The test and conditioned stimulation intervals were kept between 10 ms, 20 ms, 30 ms, 40 ms, 50 ms, 75 ms, 100 ms, 150 ms and 200 ms. In each inter-stimulus interval, nonparametric repeat measurement evaluations were conducted with the percentage value of Hc/Ht. The Hc/Ht values of the study and control groups in the same intervals were compared separately. Results: A significant decrease was detected in Hc values in the control group in the repeat measurement values at 20 ms and 100 ms inter-stimulus intervals; however, there was not decrease in any intervals in the patient's group. Conclusion: The absence of any decrease in Hc reflexes for 20-100 ms intervals revealed that discernible PreI was vanished in RLS patients.en_US
dc.identifier.doi10.1080/00207454.2020.1737048
dc.identifier.endpage219en_US
dc.identifier.issn0020-7454
dc.identifier.issn1543-5245
dc.identifier.issue3en_US
dc.identifier.pmid32108535en_US
dc.identifier.scopus2-s2.0-85081546126en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage213en_US
dc.identifier.urihttps://doi.org/10.1080/00207454.2020.1737048
dc.identifier.urihttps://hdl.handle.net/20.500.12491/10771
dc.identifier.volume131en_US
dc.identifier.wosWOS:000519425100001en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorTürkoğlu, Şule Aydın
dc.institutionauthorBolaç, Elif Sultan
dc.institutionauthorYıldız, Serpil
dc.institutionauthorKalaycıoğlu, Oya
dc.institutionauthorYıldız, Nebil
dc.language.isoenen_US
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofInternational Journal Of Neuroscienceen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectRestless Legs Syndromeen_US
dc.subjectSpinal Reflexesen_US
dc.subjectPresynaptic Inhibitionen_US
dc.titlePresynaptic inhibition in restless legs syndromeen_US
dc.typeArticleen_US

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