Efficacy of intravesical cocktail therapy with or without dimethyl sulphoxide in interstitial cystitis

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dc.authorid0000-0002-1454-5672en_US
dc.authorid0000-0002-7341-8753en_US
dc.contributor.authorSöğütdelen, Emrullah
dc.contributor.authorÇıtamak, Burak
dc.date.accessioned2024-02-09T11:34:29Z
dc.date.available2024-02-09T11:34:29Z
dc.date.issued2022en_US
dc.departmentBAİBÜ, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümüen_US
dc.description.abstractIntroduction Interstitial cystitis (IC) is a chronic bladder inflammation with unknown etiologies that impairs the quality of life of patients. We aimed to investigate the efficacy of dimethyl sulphoxide (DMSO) use in the cocktail therapy in IC patients. Material and methods Patients treated with intravesical cocktail therapy which contained a mixture of 10 mL of bupivacaine, 1 mL of heparin, and 9 mL of sodium bicarbonate, was introduced to Group 1, and, 25 mL of DMSO was added to this cocktail and introduced to Group 2. Statistical analyses between groups were assessed by Turkish validated O'Leary Sant score composed of IC Symptom Index (ICSI) and IC Problem Index (ICPI), visual analog scale (VAS) score, and short form-36 (SF-36) questionnaire in the baseline versus post-instillation week 6, month 6, and month 12, comparatively.Results A total of 62 patients (58 women and 4 men) with a median age of 52 (28-76) years were included. Baseline versus post-instillation 6th week of ICSI and ICPI scores were 15 +/- 3.4 vs 7.4 +/- 2.9 and 12.6 +/- 2.8 vs 6.1 +/- 2.7, respectively (p <0.001 and <0.001, respectively). VAS scores of Group 2 were statistically significantly lower than that of Group 1 in the post-instillation month 6 (p = 0.03) whereas, the baseline of VAS scores were similar.Conclusions Intravesical cocktail therapy is an effective and reliable treatment method and can be safely applied with or without DMSO. Adding DMSO to cocktail therapy provides a further decrease in VAS score in the post-instillation month 6.en_US
dc.identifier.citationEfficacy of intravesical cocktail therapy with or without dimethyl sulphoxide in interstitial cystitisen_US
dc.identifier.doi10.5173/ceju.2022.129
dc.identifier.endpage304en_US
dc.identifier.issn2080-4806
dc.identifier.issn2080-4873
dc.identifier.issue3en_US
dc.identifier.pmid36381159en_US
dc.identifier.scopus2-s2.0-85139477649en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage299en_US
dc.identifier.urihttp://dx.doi.org/10.5173/ceju.2022.129
dc.identifier.urihttps://hdl.handle.net/20.500.12491/12005
dc.identifier.volume75en_US
dc.identifier.wosWOS:000861295700001en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorSöğütdelen, Emrullah
dc.language.isoenen_US
dc.publisherPolish Urological Assocen_US
dc.relation.ispartofCentral European Journal of Urologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectIntravesical Cocktailen_US
dc.subjectInterstitial Cystitis Symptom Indexen_US
dc.subjectInterstitial Cystitis Problem Indexen_US
dc.subjectShort Form-36en_US
dc.subjectVisual Analog Scaleen_US
dc.subjectInterstitial Cystitisen_US
dc.titleEfficacy of intravesical cocktail therapy with or without dimethyl sulphoxide in interstitial cystitisen_US
dc.typeArticleen_US

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