The effects of triiodothyronine on rat testis: a morphometric and immunohistochemical study

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dc.authorid0000-0002-1197-2468
dc.authorid0000-0003-3310-8803
dc.authorid0000-0003-1364-4684
dc.authorid0000-0001-5387-2628
dc.authorid0000-0002-7274-5138
dc.contributor.authorÖner, Jale
dc.contributor.authorÖner, Hakan
dc.contributor.authorÇolakoğlu, Neriman
dc.contributor.authorKükner, Aysel
dc.contributor.authorOzan, Enver
dc.date.accessioned2021-06-23T19:19:35Z
dc.date.available2021-06-23T19:19:35Z
dc.date.issued2006
dc.departmentBAİBÜ, Tıp Fakültesi, Temel Tıp Bilimleri Bölümüen_US
dc.description.abstractThe aim of present study was to investigate the effects of 3,3',5-triiodothyronine (T(3)) on rat testis both morphometrically and immunohistochemically with determining of insulin-like growth factor I (IGF-I) expression. Adult male Wistar-albino rats used in the study were divided into two groups; control and T(3)-treated groups. After T(3) treatment there was observed to be a decrease in testicular weights, diameters of seminiferous tubules and the number of sertoli cells, and an increase in the number of leydig cells (P < 0.05). Some of the seminiferous tubule lumens of T(3) administrated rats had cellular debris. IGF-I was localized in sertoli cells, late spermatids and leydig cells of all groups. IGF-I immunoreactivity in T(3) treated rats was higher than in controls in all stages of the cycle of rat seminiferous epithelium, but the staining intensity of leydig cells were similar in both groups. In conclusion, the present results suggest that T(3) may modulate the testicular function by affecting IGF-I activity at the gonadal level.en_US
dc.identifier.doi10.1007/s10735-006-9020-2
dc.identifier.endpage14en_US
dc.identifier.issn1567-2379
dc.identifier.issue1-2en_US
dc.identifier.pmid16733789en_US
dc.identifier.scopus2-s2.0-33748864603en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage9en_US
dc.identifier.urihttps://doi.org/10.1007/s10735-006-9020-2
dc.identifier.urihttps://hdl.handle.net/20.500.12491/5969
dc.identifier.volume37en_US
dc.identifier.wosWOS:000240309100003en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorKükner, Aysel
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofJournal Of Molecular Histologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectIGF-Ien_US
dc.subjectT(3)en_US
dc.subjectTestisen_US
dc.titleThe effects of triiodothyronine on rat testis: a morphometric and immunohistochemical studyen_US
dc.typeArticleen_US

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