Efficacy of daptomycin on experimental methicillin-resistant staphylococcus aureus keratitis in rabbits

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dc.contributor.authorMengeloğlu, Fırat Zafer
dc.contributor.authorKüçükbayrak, Abdulkadir
dc.contributor.authorBucak, Yasin Yucel
dc.contributor.authorErdurmuş, Mesut
dc.contributor.authorTaş, Tekin
dc.contributor.authorÖzyalvaçlı, Gülzade
dc.contributor.authorBayram, Recep
dc.contributor.authorBucak , Özlem
dc.contributor.authorAkdeniz, Hayrettin
dc.date.accessioned2021-06-23T19:34:06Z
dc.date.available2021-06-23T19:34:06Z
dc.date.issued2013
dc.departmentBAİBÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.description.abstractPurpose: We aimed to compare the efficacy of topical daptomycin (DAP) with that of vancomycin (VA) in the treatment of keratitis caused by methicillin-resistant Staphylococcus aureus (MRSA). Methods: One hundred colony-forming unit MRSA bacteria were injected intrastromally into both corneas of 28 rabbits. Sixteen hours after injection, the rabbits' eyes were treated with 1 drop of topical DAP (10 or 50mg/mL), VA (50mg/mL), or isotonic saline for 19 doses. Their eyes were examined for clinical severity before and after treatment. Results: The minimum inhibitory concentration values of VA and DAP against the bacterial strain were found to be 2 and 0.5g/mL, respectively. The mean pre- and post-treatment clinical scores of the eyes did not differ significantly among the groups. However, the mean difference between the post- and pretreatment clinical scores was significantly lower in the 50mg/mL DAP group than in the other groups (P=0.042). A marked decrease in bacterial load was detected in all treatment groups compared to the control group (P=0.002). Although there were no significant differences in bacterial load among the treatment groups, the 50mg/mL DAP group showed the greatest decrease. The mean % epithelial erosion rate tended to be higher in the 50mg/mL VA group than in the other groups (P=0.31). Conclusions: Topical DAP significantly reduced the bacterial load and showed activity against MRSA comparable to that of fortified VA in this experimental model.en_US
dc.identifier.doi10.1089/jop.2013.0120
dc.identifier.endpage899en_US
dc.identifier.issn1080-7683
dc.identifier.issn1557-7732
dc.identifier.issue10en_US
dc.identifier.pmid24070366en_US
dc.identifier.scopus2-s2.0-84890061916en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage893en_US
dc.identifier.urihttps://doi.org/10.1089/jop.2013.0120
dc.identifier.urihttps://hdl.handle.net/20.500.12491/7380
dc.identifier.volume29en_US
dc.identifier.wosWOS:000327777000009en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorMengeloğlu, Fırat Zafer
dc.institutionauthorKüçükbayrak, Abdulkadir
dc.institutionauthorErdurmuş, Mesut
dc.institutionauthorTaş, Tekin
dc.institutionauthorÖzyalvaçlı, Gülzade
dc.institutionauthorBayram, Recep
dc.institutionauthorBucak , Özlem
dc.institutionauthorAkdeniz, Hayrettin
dc.language.isoenen_US
dc.publisherMary Ann Liebert, Incen_US
dc.relation.ispartofJournal Of Ocular Pharmacology And Therapeuticsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.titleEfficacy of daptomycin on experimental methicillin-resistant staphylococcus aureus keratitis in rabbitsen_US
dc.typeArticleen_US

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