Protection of urinary bladder function by grape suspension

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dc.authorid0000-0002-2577-8711
dc.contributor.authorAğartan, Canan Aldırmaz
dc.contributor.authorWhitbeck, Catherine
dc.contributor.authorSokol, Rebekah
dc.contributor.authorChichester, Paul
dc.contributor.authorLevin, Robert M.
dc.date.accessioned2021-06-23T19:17:47Z
dc.date.available2021-06-23T19:17:47Z
dc.date.issued2004
dc.departmentBAİBÜ, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümüen_US
dc.description.abstractUrinary bladder dysfunction secondary to BPH is a major affliction of aging men. A rabbit model of partial outlet obstruction was used to evaluate the ability of a standardized grape suspension to protect the bladder against obstructive bladder dysfunction. Twenty-four New Zealand White rabbits were separated into four groups of six rabbits each. Groups 1 and 3 were pretreated by oral gavage for 3 weeks with a standardized grape suspension suspended in water; groups 2 and 4 were treated with vehicle. Groups 1 and 3 received sham operations after 3 weeks of treatment; groups 2 and 4 received partial outlet obstruction by surgically placing a silk ligature loosely around the urethra. At 3 weeks following surgery, in vivo and in vitro bladder functions were evaluated. Based on both in vivo and in vitro studies, the grape suspension significantly reduced the severity of obstructed bladder dysfunction. This is consistent with the hypothesis that ischemia is a major etiological factor in obstructive dysfunction, and treatment with antioxidants and membrane stabilization compounds such as those in the grape suspension can be effective in the treatment of obstructive bladder pathology.en_US
dc.identifier.doi10.1002/ptr.1620
dc.identifier.endpage1018en_US
dc.identifier.issn0951-418X
dc.identifier.issue12en_US
dc.identifier.pmid15742347en_US
dc.identifier.scopus2-s2.0-14044256422en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage1013en_US
dc.identifier.urihttps://doi.org/10.1002/ptr.1620
dc.identifier.urihttps://hdl.handle.net/20.500.12491/5545
dc.identifier.volume18en_US
dc.identifier.wosWOS:000227252900012en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorAğartan, Canan Aldırmaz
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofPhytotherapy Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectGrapeen_US
dc.subjectResveratrolen_US
dc.subjectBladderen_US
dc.subjectObstructionen_US
dc.subjectReperfusionen_US
dc.titleProtection of urinary bladder function by grape suspensionen_US
dc.typeArticleen_US

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