Clinical importance of neuregulin-4 and its receptor ErbB4 in periodontal disease pathogenesis

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dc.authorid0000-0001-9848-0927en_US
dc.authorid0000-0002-6558-3775en_US
dc.authorid0000-0001-6100-322X
dc.contributor.authorMeracı, Bilge
dc.contributor.authorGünpınar, Şadiye
dc.contributor.authorDündar, Niyazi
dc.date.accessioned2021-06-23T19:54:19Z
dc.date.available2021-06-23T19:54:19Z
dc.date.issued2020
dc.departmentBAİBÜ, Diş Hekimliği Fakültesi, Periodontoloji Ana Bilim Dalıen_US
dc.description.abstractObjective The aim of this clinical trial was to evaluate the levels of Neuregulin-4 (Nrg4), Erb-b2 receptor tyrosine kinase 4 (ErbB4), interleukin (IL)-6, IL-10, nitric oxide synthase (NOS)-2, and arginase (Arg)-1 in periodontal health and disease. Materials and Methods This study includes systemically healthy 20 periodontally healthy (H), 20 gingivitis (G), 20 stage II periodontitis (P1), and 20 stage III periodontitis (P2) subjects. Periodontal clinical measurements and samples of gingival crevicular fluid (GCF) and serum were obtained at baseline and 4 weeks after non-surgical periodontal treatment (NSPT). Enzyme-linked immunosorbent assay (ELISA) was used to determine ErbB4, Nrg4, IL-6, IL-10, NOS2, and Arg1 levels in all samples. Results GCF ErbB4 and Nrg4 total amounts and IL-6/IL-10 ratio were significantly higher in G, P1, and P2 groups than H group. Serum NOS2 levels were significantly lower, whereas serum Arg1 levels were higher in H group than the others. The GCF levels of ErbB4 and Nrg4 were significantly decreased after NSPT in G, P1, and P2 groups. Additionally, the GCF levels of ErbB4 and Nrg4 were positively correlated with all clinical parameters and IL-6/IL-10 ratio. Conclusions Nrg4 and its receptor ErbB4 might have crucial roles in the pathogenesis of periodontal disease. These results should be verified with future prospective studies to further clarify the exact role of those biomarkers.en_US
dc.identifier.doi10.1111/odi.13349
dc.identifier.endpage1336en_US
dc.identifier.issn1354-523X
dc.identifier.issn1601-0825
dc.identifier.issue6en_US
dc.identifier.pmid32274847en_US
dc.identifier.scopus2-s2.0-85084241699en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage1326en_US
dc.identifier.urihttps://doi.org/10.1111/odi.13349
dc.identifier.urihttps://hdl.handle.net/20.500.12491/10500
dc.identifier.volume26en_US
dc.identifier.wosWOS:000528695500001en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorMeracı, Bilge
dc.institutionauthorGünpınar, Şadiye
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofOral Diseasesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectErbB-4en_US
dc.subjectGingival Crevicular Fluiden_US
dc.subjectMacrophageen_US
dc.subjectNeuregulin-4en_US
dc.subjectPeriodontal Diseaseen_US
dc.titleClinical importance of neuregulin-4 and its receptor ErbB4 in periodontal disease pathogenesisen_US
dc.typeArticleen_US

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