Correlation of proliferating cell nuclear antigen and bcl-2 expression with tumor front grading and metastasis in laryngeal squamous cell carcinoma

dc.authorid0000-0003-4096-4261
dc.authorid0000-0001-6621-3920
dc.authorid0000-0002-1958-9463
dc.authorid0000-0003-4503-3810
dc.contributor.authorBoran, Çetin
dc.contributor.authorYıldız, Levent
dc.contributor.authorKandemir, Bedri
dc.contributor.authorKaragöz, Filiz
dc.contributor.authorBarış, Sancar
dc.contributor.authorAydın, Oğuz
dc.date.accessioned2021-06-23T19:17:44Z
dc.date.available2021-06-23T19:17:44Z
dc.date.issued2003
dc.departmentBAİBÜ, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümüen_US
dc.description.abstractThis study was designed to examine the immunohistochemical expression of proliferating cell nuclear antigen (PCNA) and bcl-2 protein in 45 cases with advanced laryngeal squamous cell carcinoma who had undergone total laryngectomy with unilateral modified radical neck dissection, and the relation of this expression to some prognostic factors such as tumor front grading and neck lymph node metastases. Sections were reevaluated for routine histologic grade, tumor front grading and neck lymph node metastases, and were stained with monoclonal antibodies against PCNA and bcl-2. Significant correlation was present between the severity of PCNA expression and incidence of lymph node metastasis (p<0.05). No correlation was found between the severity of PCNA expression and tumor front grading. Bcl-2 expression did not associate with either parameters. In conclusion, PCNA is important in predicting prognosis and no association is present between the bcl-2 protein expression and prognostic factors.en_US
dc.identifier.endpage143en_US
dc.identifier.issn0028-2685
dc.identifier.issue2en_US
dc.identifier.pmid12740649en_US
dc.identifier.scopus2-s2.0-0038328851en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage139en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12491/5525
dc.identifier.urihttps://www.sav.sk/journals/neo/2003_02/NEO10.pdf
dc.identifier.volume50en_US
dc.identifier.wosWOS:000182860700010en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorBoran, Çetin
dc.language.isoenen_US
dc.publisherVeda, Slovak Academy Sciencesen_US
dc.relation.ispartofNeoplasmaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectLaryngeal Carcinomaen_US
dc.subjectPrognosisen_US
dc.subjectTumor Front Gradingen_US
dc.subjectNeck Lymph Node Metastasesen_US
dc.subjectBcl-2 Proteinen_US
dc.subjectPCNAen_US
dc.titleCorrelation of proliferating cell nuclear antigen and bcl-2 expression with tumor front grading and metastasis in laryngeal squamous cell carcinomaen_US
dc.typeArticleen_US

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