Mechanism of inhibition of CYP1A1 and glutathione s-transferase activities in fish Liver by quercetin, resveratrol, naringenin, hesperidin, and rutin

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dc.contributor.authorArınç, Emel
dc.contributor.authorYılmaz, Duygu
dc.contributor.authorBozcaarmutlu, Azra
dc.date.accessioned2021-06-23T19:42:23Z
dc.date.available2021-06-23T19:42:23Z
dc.date.issued2015
dc.departmentBAİBÜ, Fen Edebiyat Fakültesi, Kimya Bölümüen_US
dc.description.abstractQuercetin, resveratrol, naringenin, hesperidin, and rutin are phenolic compounds/flavonoids that may have roles in the reduction of cancer susceptibility. In this study, in vitro modulatory effects of them were studied on liver CYP1A1 associated 7-ethoxyresorufin-O-deethylase (EROD) activity and glutathione S-transferase (GST) activity of leaping mullet (Liza saliens). All of the phenolic compounds/flavonoids used exerted an inhibitory effect on both EROD and GST activities of fish. Quercetin, resveratrol, hesperidin, and rutin were found to inhibit EROD activity in a competitive manner; on the other hand, naringenin was found to inhibit EROD activity in a noncompetitive manner. Ki values of quercetin, resveratrol, naringenin, hesperidin, and rutin were calculated from Dixon plots as 0.12 mu M, 0.67 mu M, 2.63 mu M, 18 mu M and 0.1mM, respectively. Resveratrol, quercetin, and hesperidin were found to inhibit GST activity in a competitive manner; on the other hand, rutin and naringenin were found to inhibit GST activity in a mixed-type manner. Ki values of resveratrol, quercetin, hesperidin, naringenin, and rutin were calculated from Dixon plots as 3.2 mu M, 12.5 mu M, 45 mu M, 128 mu M, and 150 mu M, respectively. The results suggest that quercetin and resveratrol containing foods are effective in the prevention and treatment of cancer.en_US
dc.identifier.doi10.1080/01635581.2015.965335
dc.identifier.endpage144en_US
dc.identifier.issn0163-5581
dc.identifier.issn1532-7914
dc.identifier.issue1en_US
dc.identifier.pmid25372667en_US
dc.identifier.scopus2-s2.0-84920549085en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage137en_US
dc.identifier.urihttps://doi.org/10.1080/01635581.2015.965335
dc.identifier.urihttps://hdl.handle.net/20.500.12491/8465
dc.identifier.volume67en_US
dc.identifier.wosWOS:000347043500015en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorBozcaarmutlu, Azra
dc.language.isoenen_US
dc.publisherRoutledge Journals, Taylor & Francis Ltden_US
dc.relation.ispartofNutrition And Cancer-An International Journalen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.titleMechanism of inhibition of CYP1A1 and glutathione s-transferase activities in fish Liver by quercetin, resveratrol, naringenin, hesperidin, and rutinen_US
dc.typeArticleen_US

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