Mechanism of inhibition of CYP1A1 and glutathione s-transferase activities in fish Liver by quercetin, resveratrol, naringenin, hesperidin, and rutin
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Dosyalar
Tarih
2015
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Routledge Journals, Taylor & Francis Ltd
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Quercetin, resveratrol, naringenin, hesperidin, and rutin are phenolic compounds/flavonoids that may have roles in the reduction of cancer susceptibility. In this study, in vitro modulatory effects of them were studied on liver CYP1A1 associated 7-ethoxyresorufin-O-deethylase (EROD) activity and glutathione S-transferase (GST) activity of leaping mullet (Liza saliens). All of the phenolic compounds/flavonoids used exerted an inhibitory effect on both EROD and GST activities of fish. Quercetin, resveratrol, hesperidin, and rutin were found to inhibit EROD activity in a competitive manner; on the other hand, naringenin was found to inhibit EROD activity in a noncompetitive manner. Ki values of quercetin, resveratrol, naringenin, hesperidin, and rutin were calculated from Dixon plots as 0.12 mu M, 0.67 mu M, 2.63 mu M, 18 mu M and 0.1mM, respectively. Resveratrol, quercetin, and hesperidin were found to inhibit GST activity in a competitive manner; on the other hand, rutin and naringenin were found to inhibit GST activity in a mixed-type manner. Ki values of resveratrol, quercetin, hesperidin, naringenin, and rutin were calculated from Dixon plots as 3.2 mu M, 12.5 mu M, 45 mu M, 128 mu M, and 150 mu M, respectively. The results suggest that quercetin and resveratrol containing foods are effective in the prevention and treatment of cancer.
Açıklama
Anahtar Kelimeler
Kaynak
Nutrition And Cancer-An International Journal
WoS Q Değeri
Q3
Scopus Q Değeri
Q2
Cilt
67
Sayı
1
