Do low vitamin D levels facilitae renal parenchymal injury?

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dc.authorid0000-0003-2469-9509
dc.authorid0000-0003-1719-5994
dc.authorid0000-0002-9026-4485
dc.contributor.authorBekdaş, Mervan
dc.contributor.authorÇalışkan, Billur
dc.contributor.authorKarabörk, Şeyda
dc.contributor.authorAcar, Seher
dc.contributor.authorKabakuş, Nimet
dc.date.accessioned2021-06-23T19:54:06Z
dc.date.available2021-06-23T19:54:06Z
dc.date.issued2020
dc.departmentBAİBÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.description.abstractBackground Decreased vitamin D levels lead to an increase in infectious diseases, including urinary tract infections (UTIs). Objective To assess serum vitamin D levels in children with renal parenchymal injury secondary to UTIs. Methods Forty-three upper UTI patients and 24 controls, aged 1-15 years, were included. Vitamin D levels and other laboratory tests were obtained when they first admitted to hospital. 99mTc-labeled dimercaptosuccinic acid (DMSA) scans were performed to evaluate renal parenchymal injury. Results Mean serum 25-hydroxyvitamin D (25 (OH)D) was lower in the upper UTI group compared to the control group [18 (SD 9) vs. 23 (SD 10.6) ng/mL, respectively; P=0.045]. The upper UTI group was sub-divided into two groups, those with 22 (51.1%) and without 21 (48.8%) renal parenchymal injury. Mean 25(OH)D was significantly lower in patients with renal parenchymal injury [15.1 (SD 7.1) vs. 21 (SD 9.9) ng/mL, respectively; P=0.0.3]. The renal parenchymal injury cases were further sub-divided into two groups: 8 patients (36.3%) with acute renal parenchymal injury and 14 (63.6%) with renal scarring (RS), but there was no significant difference in 25(OH)D between these two groups [12.5 (SD 8.9) vs. 16.6 (SD 5.7) ng/mL, respectively; P=0.14). Conclusion Decreased vitamin D is associated with renal parenchymal injury in children with upper UTIs. However, vitamin D is not significantly decreased in renal scarring patients compared to acute renal parenchymal injury patients.en_US
dc.identifier.doi10.14238/pi60.4.2020.205-11
dc.identifier.endpage211en_US
dc.identifier.issn0030-9311
dc.identifier.issn2338-476X
dc.identifier.issue4en_US
dc.identifier.scopus2-s2.0-85102177529en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage205en_US
dc.identifier.urihttps://doi.org/10.14238/pi60.4.2020.205-11
dc.identifier.urihttps://hdl.handle.net/20.500.12491/10419
dc.identifier.volume60en_US
dc.identifier.wosWOS:000557490500007en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.institutionauthorBekdaş, Mervan
dc.institutionauthorAcar, Seher
dc.institutionauthorKabakuş, Nimet
dc.institutionauthorÇalışkan, Billur
dc.language.isoenen_US
dc.publisherIndonesian Pediatric Soc Publishing Houseen_US
dc.relation.ispartofPaediatrica Indonesianaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectChilden_US
dc.subjectUpper UTIen_US
dc.subjectRenal Injuryen_US
dc.subjectVitamin Den_US
dc.titleDo low vitamin D levels facilitae renal parenchymal injury?en_US
dc.typeArticleen_US

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