Evaluation of different p16 immunostaining methods and the prognostic role of p16/Ki-67 combined expression in non-muscle invasive bladder cancers

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dc.authorid0000-0001-8590-4831
dc.authorid0000-0002-6553-4500
dc.authorid0000-0003-4096-4261
dc.authorid0000-0002-4313-8478
dc.contributor.authorÖzyalvaçlı, Gülzade
dc.contributor.authorÖzyalvaçlı, Mehmet Emin
dc.contributor.authorAstarcı, Hesna Müzeyyen
dc.contributor.authorBoran, Çetin
dc.contributor.authorYeşil, Cemile
dc.contributor.authorÜyetürk, Uğur
dc.contributor.authorAktaş, Gülan
dc.date.accessioned2021-06-23T19:42:14Z
dc.date.available2021-06-23T19:42:14Z
dc.date.issued2015
dc.departmentBAİBÜ, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümüen_US
dc.description.abstractThere are many scoring methods evaluating the expression of p16 in the bladder immunohistochemically. In this study our aim was to determine an optimal p16 scoring method by discussing different staining methods related with p16 expression in bladder cancers and to establish the association of p16 and Ki-67 expressions, alone or in combination, with recurrence and progression. Ninety patients undergoing their first transurethral resection for bladder cancer and newly diagnosed papillary urothelial carcinoma (pTa and pT1) were included in the study. Four different scoring methods were used for p16 (p16a, p16b, p16c, p16d). The patients were divided into two groups based on recurrence and progression. There was a statistically significant difference between recurrence and abnormal p16d staining (p = 0.005). In other staining patterns of p16, there was no statistically significant difference in terms of recurrence or progression.In the multivariate logistic regression analysis, combined Ki-67 >= 10 and abnormal p16d staining was found to be the only independent predictive factor for recurrence (OR = 2.26, 95% CI: 0.13-46.41, p = 0.035) and no independent predictive factor for progression was found. Determining an adequate expression scoring by taking normal transitional epithelial staining pattern as a reference would be an objective approach in p16 evaluation. Moreover, it was found that evaluating p16d and Ki-67 in combination would be significant in predicting recurrence in pTa and pT1 urothelial carcinomas.en_US
dc.identifier.doi10.5114/PJP.2015.51154
dc.identifier.endpage66en_US
dc.identifier.issn1233-9687
dc.identifier.issue1en_US
dc.identifier.pmid26017881en_US
dc.identifier.scopus2-s2.0-84929415075en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage57en_US
dc.identifier.urihttps://doi.org/10.5114/PJP.2015.51154
dc.identifier.urihttps://hdl.handle.net/20.500.12491/8406
dc.identifier.volume66en_US
dc.identifier.wosWOS:000354418400009en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorÖzyalvaçlı, Gülzade
dc.institutionauthorÖzyalvaçlı, Mehmet Emin
dc.institutionauthorAstarcı, Hesna Müzeyyen
dc.institutionauthorBoran, Çetin
dc.institutionauthorÜyetürk, Uğur
dc.institutionauthorAktaş, Gülan
dc.language.isoenen_US
dc.publisherVesalius Univ Medical Publen_US
dc.relation.ispartofPolish Journal Of Pathologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectBladder Canceren_US
dc.subjectKi-67en_US
dc.subjectp16INK4Aen_US
dc.subjectProgressionen_US
dc.subjectRecurrenceen_US
dc.titleEvaluation of different p16 immunostaining methods and the prognostic role of p16/Ki-67 combined expression in non-muscle invasive bladder cancersen_US
dc.typeArticleen_US

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