Biomechanical factors in psoriatic disease: Defective repair exertion as a potential cause. Hypothesis presentation and literature review

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dc.authorid0000-0003-0290-9341
dc.contributor.authorTönük, Şükrü Burak
dc.contributor.authorYorgancıoğlu, Zeynep Rezan
dc.date.accessioned2024-09-25T20:01:30Z
dc.date.available2024-09-25T20:01:30Z
dc.date.issued2019
dc.departmentBAİBÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü en_US
dc.description.abstractJoining main clinical manifestations of psoriatic skin disorder are inflammatory arthritis and nail lesions. Repetitive microdamage has been postulated as a main triggering factor in lesions of psoriatic arthritis. This concept of psoriatic disease might also be admissible for triggering nail lesions because the nail is a frequently traumatized structure. Here, we aimed to describe the conjectural injury mechanisms of nail complex with regard to acting biomechanical factors. Tissue repair response to physical microdamage may be altered in psoriatic disease. It is plausible to consider that a defective repair process in the dysregulated prepsoriatic tissue may lead to innate immune activation and further development of autoinflammatory lesions, although excessive inflammation is known to impair wound healing. Recently published data have revealed the importance of mechanosensitive Wingless-type (Wnt) signaling in the pathophysiology of psoriasis and ankylosing spondylitis. The Wnt signaling system is involved in morphogenesis, repair, and regeneration as a biologic process main regulator. Wnt5a seems to be a dominating mediator in both psoriatic plaques and during the spondylitis process that might also be a linking molecule of psoriatic response to mechanical stress. Future studies should focus on complex responsive interactions of tissue repair regulators regarded in psoriatic disease.en_US
dc.description.sponsorshipAll authors thank Prof. R. Orhan Yldrm (Middle East Technical University, Ankara, Turkey) for his review.en_US
dc.identifier.doi10.1002/acr2.11056
dc.identifier.endpage461en_US
dc.identifier.issn2578-5745
dc.identifier.issue7en_US
dc.identifier.pmid31777825en_US
dc.identifier.scopus2-s2.0-85119142820en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage452en_US
dc.identifier.urihttps://doi.org/10.1002/acr2.11056
dc.identifier.urihttps://hdl.handle.net/20.500.12491/14167
dc.identifier.volume1en_US
dc.identifier.wosWOS:001299661100004en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorTönük, Şükrü Burak
dc.institutionauthorid0000-0003-0290-9341
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofAcr Open Rheumatologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.snmzYK_20240925en_US
dc.subjectAnkylosing Spondylitis
dc.subjectBiologic Process
dc.subjectWingless-Type
dc.subjectPsoriatic Disease
dc.subjectPathophysiology
dc.subjectMorphogenesis
dc.titleBiomechanical factors in psoriatic disease: Defective repair exertion as a potential cause. Hypothesis presentation and literature reviewen_US
dc.typeReview Articleen_US

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