Clinicopathological profile of gastrointestinal tuberculosis: a multinational ID-IRI study

dc.authorid0000-0002-6279-1018en_US
dc.authorid0000-0002-8977-5931en_US
dc.authorid0000-0002-7697-6849en_US
dc.authorid0000-0002-6265-5227en_US
dc.authorid0000-0002-7477-6640en_US
dc.authorid0000-0002-1992-1796en_US
dc.authorid0000-0002-6005-636X
dc.contributor.authorTanoğlu, Alpaslan
dc.contributor.authorErdem, Hakan
dc.contributor.authorFriedland, Jon S.
dc.contributor.authorAlmajid, Fahad M.
dc.contributor.authorBatırel, Ayşe
dc.contributor.authorKulzhanova, Sholpan
dc.contributor.authorKonkayeva, Maiya
dc.contributor.authorSırmatel, Fatma
dc.date.accessioned2021-06-23T19:54:59Z
dc.date.available2021-06-23T19:54:59Z
dc.date.issued2020
dc.departmentBAİBÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.description.abstractData are relatively scarce on gastro-intestinal tuberculosis (GITB). Most studies are old and from single centers, or did not include immunosuppressed patients. Thus, we aimed to determine the clinical, radiological, and laboratory profiles of GITB. We included adults with proven GITB treated between 2000 and 2018. Patients were enrolled from 21 referral centers in 8 countries (Belgium, Egypt, France, Italy, Kazakhstan, Saudi Arabia, UK, and Turkey). One hundred four patients were included. Terminal ileum (n = 46, 44.2%), small intestines except terminal ileum (n = 36, 34.6%), colon (n = 29, 27.8%), stomach (n = 6, 5.7%), and perianal (one patient) were the sites of GITB. One-third of all patients were immunosuppressed. Sixteen patients had diabetes, 8 had chronic renal failure, 5 were HIV positive, 4 had liver cirrhosis, and 3 had malignancies. Intestinal biopsy samples were cultured in 75 cases (78.1%) and TB was isolated in 65 patients (86.6%). PCR were performed to 37 (35.6%) biopsy samples and of these, 35 (94.6%) were positive. Ascites samples were cultured in 19 patients and M. tuberculosis was isolated in 11 (57.9%). Upper gastrointestinal endoscopy was performed to 40 patients (38.5%) and colonoscopy in 74 (71.1%). Surgical interventions were frequently the source of diagnostic samples (25 laparoscopy/20 laparotomy, n = 45, 43.3%). Patients were treated with standard and second-line anti-TB medications. Ultimately, 4 (3.8%) patients died and 2 (1.9%) cases relapsed. There was a high incidence of underlying immunosuppression in GITB patients. A high degree of clinical suspicion is necessary to initiate appropriate and timely diagnostic procedures; many patients are first diagnosed at surgery.en_US
dc.identifier.doi10.1007/s10096-019-03749-y
dc.identifier.endpage500en_US
dc.identifier.issn0934-9723
dc.identifier.issn1435-4373
dc.identifier.issue3en_US
dc.identifier.pmid31758440en_US
dc.identifier.scopus2-s2.0-85075375311en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage493en_US
dc.identifier.urihttps://doi.org/10.1007/s10096-019-03749-y
dc.identifier.urihttps://hdl.handle.net/20.500.12491/10700
dc.identifier.volume39en_US
dc.identifier.wosWOS:000498049600005en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorSırmatel, Fatma
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofEuropean Journal Of Clinical Microbiology & Infectious Diseasesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectTuberculosisen_US
dc.subjectImmune-suppressionen_US
dc.subjectGastro-intestinalen_US
dc.subjectEndoscopyen_US
dc.subjectTreatmenten_US
dc.titleClinicopathological profile of gastrointestinal tuberculosis: a multinational ID-IRI studyen_US
dc.typeArticleen_US

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