‘Immune-inflammatory markers & clinical characteristics for outcomes in hospitalized SARS-CoV-2 infected patients of Pakistan: a retrospective analysis'
Yükleniyor...
Dosyalar
Tarih
2023
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Taylor& Francis
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Objective: Accumulating evidence suggests the role of immune-inflammatory markers in early
risk stratification and prognostication of COVID-19 patients. We aimed to evaluate their
association with severity and the development of diagnostic scores with optimal thresholds
in critical patients.
Setting and participants: This retrospective case study includes hospitalized COVID-19
patients from March 2019 to March, 2022, in the developing area teaching hospital in
Pakistan. Polymerase chain reaction (PCR) positive patients, n = 467 were investigated for
clinical outcomes, comorbidities and disease prognosis. The plasma levels of Interleukin-6
(IL-6), Lactate dehydrogenase (LDH), C-reactive protein (CRP), Procalcitonin (PCT), ferritin and
Complete blood count markers were measured.
Results: Majority were males (58.8%) and patients with comorbidities had more severe disease.
Hypertension and diabetes mellitus were the commonest comorbidities. Shortness of breath,
myalgia and cough were the main symptoms. The hematological markers NLR, as well as the
plasma levels of immune-inflammatory variables, IL-6, LDH, Procalcitonin, Erythrocyte
sedimentation rate, Ferritin were markedly raised in severe and critical patients (p < 0.0001 for
these markers). ROC analysis supports IL-6 as the most accurate marker with high prognostic
relevance with proposed cut-off threshold (43 pg/ml), determining >90% of patients in terms
of COVID-19 severity (AUC = 0.93, 91.7%, se; 90.3%sp). Furthermore, positive correlation with all
other markers including NLR with cut-off = 2.99 (AUC = 0.87, se = 89.8%, sp = 88.4%), CRP with
cut-offs at 42.9 mg/l, (AUC = 0.883, se = 89.3% and sp = 78.6%), LDH cut-off at 267μg/L,
evidenced in >80% patients (AUC = 0.834 se = 84% and sp = 80%). Additionally, ESR and ferritin
have the corresponding AUC 0.81 and 0.813 with cut-off at 55 mm/hr and 370, respectively.
Conclusion: Investigating the immune-inflammatory markers can assist physicians in providing
prompt treatment and ICU admission in terms of COVID-19 severity. As a result, which may
reduce the overall mortality of COVID-19 patients.
Abbreviations: CBCs: complete blood counts; PCTs: Procalcitonin; CRP: C-reactive protein; LDH:
Lactate dehydrogenase; ESR: Erythrocyte sedimentation rate; LDH: Lactate dehydrogenase; CRP:
C-reactive Protein; NLR: Neutrophil to Lymphocyte ratio; se: sensitivity; sp: specificity
Açıklama
Anahtar Kelimeler
COVID-19, SARS-CoV-2, Immune-Inflammatory Markers, Disease Severity, Diagnostic Criteria
Kaynak
Hematology
WoS Q Değeri
Q3
Scopus Q Değeri
Q3
Cilt
28
Sayı
1
Künye
Khalid, A., Aqeel, R. F., Nawaz, A., Ahmad, J., Fatima, S. T., Shahid, S., ... & Shehryar, M. (2023). Immune-inflammatory markers & clinical characteristics for outcomes in hospitalized SARS-CoV-2 infected patients of Pakistan: a retrospective analysis. Hematology, 28(1), 2199629. DOI: 10.1080/16078454.2023.2199629
