Oleanolic acid suppresses pentylenetetrazole-induced seizure in vivo

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dc.authorid0000-0001-8791-235Xen_US
dc.authorid0000-0003-1075-9574en_US
dc.contributor.authorTürel, Canan Akünal
dc.contributor.authorYunusoğlu, Oruç
dc.date.accessioned2023-11-30T11:50:44Z
dc.date.available2023-11-30T11:50:44Z
dc.date.issued2023en_US
dc.departmentBAİBÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.description.abstractThe aim of this study was to investigate the protective effects of triterpene oleanolic acid on the brain tissue of mice with pentylenetetrazole (PTZ)-induced epileptic seizures. Male Swiss albino mice were randomly separated into five groups as the PTZ, control, and oleanolic acid (10, 30, and 100 mg/kg) groups. PTZ injection was seen to cause significant seizures compared with the control group. Oleanolic acid significantly prolonged the latency to onset of myoclonic jerks and the duration of clonic convulsions, and decreased mean seizure scores following PTZ administration. Pretreatment with oleanolic acid also led to an increase in antioxidant enzyme activity (CAT and AChE) and levels (GSH and SOD) in the brain. The data obtained from this study support oleanolic acid may have anticonvulsant potential in PTZ-induced seizures, prevent oxidative stress and protect against cognitive disturbances. These results may provide useful information for the inclusion of oleanolic acid in epilepsy treatment.en_US
dc.identifier.citationAkünal Türel, C., & Yunusoğlu, O. (2023). Oleanolic acid suppresses pentylenetetrazole-induced seizure in vivo. International Journal of Environmental Health Research, 33(5), 529-540.en_US
dc.identifier.doi10.1080/09603123.2023.2167947
dc.identifier.endpage540en_US
dc.identifier.issn0960-3123
dc.identifier.issn1369-1619
dc.identifier.issue5en_US
dc.identifier.pmid36812380en_US
dc.identifier.scopus2-s2.0-85148594442en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage529en_US
dc.identifier.urihttp://dx.doi.org/10.1080/09603123.2023.2167947
dc.identifier.urihttps://hdl.handle.net/20.500.12491/11893
dc.identifier.volume33en_US
dc.identifier.wosWOS:000935236200001en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorTürel, Canan Akünal
dc.institutionauthorYunusoğlu, Oruç
dc.language.isoenen_US
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofInternational Journal of Environmental Health Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectEpilepsyen_US
dc.subjectPentylenetetrazolen_US
dc.subjectOleanolic Aciden_US
dc.subjectPPAR-Gammaen_US
dc.subjectLung Injuryen_US
dc.subjectEpilepsyen_US
dc.subjectReceptoren_US
dc.titleOleanolic acid suppresses pentylenetetrazole-induced seizure in vivoen_US
dc.typeArticleen_US

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