Role of epicardial fat thickness for prediction of proliferative diabetic retinopathy

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dc.authorid0000-0003-1148-6969en_US
dc.authorid0000-0002-6965-7444en_US
dc.authorid0000-0002-8249-2621en_US
dc.authorid0000-0003-4468-3985en_US
dc.authorid0000-0003-3817-851Xen_US
dc.authorid0000-0003-2399-9585en_US
dc.contributor.authorSincer, Abide
dc.contributor.authorKaygusuz, Tuba
dc.contributor.authorAlkan, Yunus
dc.contributor.authorCoşgun, Mehmet
dc.contributor.authorDoğan, Ümit
dc.contributor.authorUlaş, Fatih
dc.contributor.authorSincer, İsa
dc.contributor.authorGüneş, Yılmaz
dc.date.accessioned2023-08-15T07:55:47Z
dc.date.available2023-08-15T07:55:47Z
dc.date.issued2023en_US
dc.departmentBAİBÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.description.abstractPurpose Plenty of factors including inflammation are responsible for development of diabetic retinopathy (DR). Epicardial fat produces adipokines, cytokines and inflammatory products. Monocyte count to high density lipoprotein (HDL) ratio (MHR) has been recently suggested as an inflammatory marker. Methods Epicardial fat thickness (EFT) and MHR were analyzed in 36 diabetics without DR (NDR), 35 diabetics with proliferative DR (PDR) and 41 diabetics with nonproliferative DR patients (nonPDR). Results Monocyte counts, HDL, mean MHR and EFT values of NDR, nonPDR and PDR groups were significantly different. One-way analysis of variance test with post hoc Tukey test revealed that the significance of differences in MHR and EFT were dependent on the differences between NDR and PDR (p<0.001 for both) and nonPDR and PDR groups (pp=0.001). The differences between NDR and nonPDR (p=0.81 and p=0.06) were not significant. MHR and EFT were significantly positively correlated with PDR (r=0.453, pr=0.394, p<0.001) and negatively correlated with NDR (r=-0.256, p=0.006 and r= -0.380, p<0.001). Only EFT was found to be independently associated with PDR (p=0.002, 95% CI: OR: 1.643 (1.206-2.237)). An EFT value of >5.90 mm classified the presence of PDR with a sensitivity 74% and specificity of 61% (AUC = 0.750, 95% CI, 0.658-0.843), and a MHR value of >12.8 ratio classified the presence of PDR with a sensitivity of 83% and a specificity of 79% (AUC = 0.811, 95% CI, 0.728-0.893). Conclusion We suggest that MHR and EFT were significantly increased in proliferative DR, and increased EFT may predict the presence of PDR in type 2 DM.en_US
dc.identifier.citationAbide, S., Tuba, K., Yunus, A., Mehmet, C., Umit, D., Fatih, U., ... & Sincer, I. (2022). Role of epicardial fat thickness for prediction of proliferative diabetic retinopathy. International Journal of Diabetes in Developing Countries, 1-5.en_US
dc.identifier.doi10.1007/s13410-021-01040-5
dc.identifier.endpage24en_US
dc.identifier.issn0973-3930
dc.identifier.issn1998-3832
dc.identifier.issue1en_US
dc.identifier.scopus2-s2.0-85122620293en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage20en_US
dc.identifier.urihttp://dx.doi.org/10.1007/s13410-021-01040-5
dc.identifier.urihttps://hdl.handle.net/20.500.12491/11520
dc.identifier.volume43en_US
dc.identifier.wosWOS:000740596300001en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.institutionauthorCoşgun, Mehmet
dc.institutionauthorDoğan, Ümit
dc.institutionauthorUlaş, Fatih
dc.institutionauthorGüneş, Yılmaz
dc.institutionauthorSincer, İsa
dc.language.isoenen_US
dc.publisherSpringer Indiaen_US
dc.relation.ispartofInternational Journal of Diabetes in Developing Countriesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectEpicardial Fat Thicknessen_US
dc.subjectDiabetic Retinopathyen_US
dc.subjectMonocyte to HDL Ratioen_US
dc.titleRole of epicardial fat thickness for prediction of proliferative diabetic retinopathyen_US
dc.typeArticleen_US

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