Cathepsin enzymes and cystatin C : Do they play a role in positive arterial remodeling?

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dc.authorid0000-0002-2417-9880en_US
dc.contributor.authorYetkin, Ertan
dc.contributor.authorWaltenberger, Johannes
dc.date.accessioned2021-06-23T19:26:26Z
dc.date.available2021-06-23T19:26:26Z
dc.date.issued2009
dc.departmentBAİBÜ, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümüen_US
dc.description.abstractWe have read the impressive article recently published by Aoki et al1 evaluating the cathepsin enzyme system in cerebral aneurysm formation. By using quantitative RT-PCR and im munohistochemistry, the authors have demonstrated increased expression of cathepsin B, cathepsin K, and cathepsin S in arterial wall of the cerebral aneurysms, whereas the expres sion of cystatin C was found to be decreased. These findings suggest an imbalance between cysteine cathepsins and their inhibitor. This imbalance may cause the excessive breakdown of extracellular matrix in the arterial wall resulting in pro gressing arterial aneurysm formation. This conclusion was supported by the experimental use of the cathepsin inhibitor NC-2300.en_US
dc.identifier.doi10.1161/STROKEAHA.108.537423
dc.identifier.endpageE27en_US
dc.identifier.issn0039-2499
dc.identifier.issue2en_US
dc.identifier.pmid19095980en_US
dc.identifier.startpageE26en_US
dc.identifier.urihttps://doi.org/10.1161/STROKEAHA.108.537423
dc.identifier.urihttps://hdl.handle.net/20.500.12491/6542
dc.identifier.volume40en_US
dc.identifier.wosWOS:000262784900059en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorYetkin, Ertan
dc.language.isoenen_US
dc.publisherLippincott Williams & Wilkinsen_US
dc.relation.ispartofStrokeen_US
dc.relation.publicationcategoryDiğeren_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectCathepsin Enzymesen_US
dc.titleCathepsin enzymes and cystatin C : Do they play a role in positive arterial remodeling?en_US
dc.typeLetteren_US

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