Cathepsin enzymes and cystatin C : Do they play a role in positive arterial remodeling?
Yükleniyor...
Dosyalar
Tarih
2009
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Lippincott Williams & Wilkins
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
We have read the impressive article recently published by
Aoki et al1 evaluating the cathepsin enzyme system in cerebral
aneurysm formation. By using quantitative RT-PCR and im munohistochemistry, the authors have demonstrated increased
expression of cathepsin B, cathepsin K, and cathepsin S in
arterial wall of the cerebral aneurysms, whereas the expres sion of cystatin C was found to be decreased. These findings
suggest an imbalance between cysteine cathepsins and their
inhibitor. This imbalance may cause the excessive breakdown
of extracellular matrix in the arterial wall resulting in pro gressing arterial aneurysm formation. This conclusion was
supported by the experimental use of the cathepsin inhibitor
NC-2300.
Açıklama
Anahtar Kelimeler
Cathepsin Enzymes
Kaynak
Stroke
WoS Q Değeri
Q1
Scopus Q Değeri
Cilt
40
Sayı
2
