Characteristics and predictors of chronic kidney disease in children with myelomeningocele: A nationwide cohort study

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dc.authorid0000-0002-6280-4587en_US
dc.authorid0000-0001-6750-8886en_US
dc.authorid0000-0002-8480-2267en_US
dc.contributor.authorTayfur, Aslı Çelebi
dc.contributor.authorDoğan, Çağla Serpil
dc.contributor.authorTaner, Sevgin
dc.contributor.authorTiryaki, Betül Durucu
dc.contributor.authorAlaygut, Demet
dc.contributor.authorÖzkayın, Neşe
dc.date.accessioned2024-05-07T12:43:47Z
dc.date.available2024-05-07T12:43:47Z
dc.date.issued2023en_US
dc.departmentBAİBÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.description.abstractBackground Myelomeningocele (MMC) is highly prevalent in developing countries, and MMC-related neurogenic bladder is an important cause of childhood chronic kidney disease (CKD). This nationwide study aimed to evaluate demographic and clinical features of pediatric patients with MMC in Turkey and risk factors associated with CKD stage 5.Methods Data from children aged 0-19 years old, living with MMC in 2022, were retrospectively collected from 27 pediatric nephrology centers. Patients > 1 year of age without pre-existing kidney abnormalities were divided into five groups according to eGFR; CKD stages 1-5. Patients on dialysis, kidney transplant recipients, and those with eGFR < 15 ml/min/1.73 m2 but not on kidney replacement therapy at time of study constituted the CKD stage 5 group.Results A total of 911 (57.8% female) patients were enrolled, most of whom were expectantly managed. Stages 1-4 CKD were found in 34.3%, 4.2%, 4.1%, and 2.4%, respectively. CKD stage 5 was observed in 5.3% of patients at median 13 years old (range 2-18 years). Current age, age at first abnormal DMSA scan, moderate-to-severe trabeculated bladder on US and/or VCUG, and VUR history were independent risk factors for development of CKD stage 5 (OR 0.752; 95%; CI 0.658-0.859; p < 0.001; OR 1.187; 95% CI 1.031-1.367; p = 0.017; OR 10.031; 95% CI 2.210-45.544; p = 0.003; OR 2.722; 95% CI 1.215-6.102; p = 0.015, respectively). Only eight CKD stage 5 patients underwent surgery related to a hostile bladder between 1 and 15 years old.Conclusion MMC-related CKD is common in childhood in Turkey. A proactive approach to neurogenic bladder management and early protective surgery in selected cases where conservative treatment has failed should be implemented to prevent progressive kidney failure in the pediatric MMC population in our country.en_US
dc.identifier.citationDoğan, Ç. S., Taner, S., Tiryaki, B. D., Alaygut, D., Özkayın, N., Kara, A., ... & Çalışkan, S. (2024). Characteristics and predictors of chronic kidney disease in children with myelomeningocele: a nationwide cohort study. Pediatric Nephrology, 39(5), 1509-1519.en_US
dc.identifier.doi10.1007/s00467-023-06212-5
dc.identifier.endpage1519en_US
dc.identifier.issn0931-041X
dc.identifier.issn1432-198X
dc.identifier.pmid38040872en_US
dc.identifier.scopus2-s2.0-85178420777en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage1509en_US
dc.identifier.urihttp://dx.doi.org/10.1007/s00467-023-06212-5
dc.identifier.urihttps://hdl.handle.net/20.500.12491/12128
dc.identifier.volume39en_US
dc.identifier.wosWOS:001112566400001en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorTayfur, Aslı Çelebi
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofPediatric Nephrologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectChilden_US
dc.subjectMyelomeningoceleen_US
dc.subjectNeurogenic Bladderen_US
dc.subjectPredictorsen_US
dc.subjectChronic Kidney Diseaseen_US
dc.subjectSpina-Bifidaen_US
dc.subjectAdolescentsen_US
dc.titleCharacteristics and predictors of chronic kidney disease in children with myelomeningocele: A nationwide cohort studyen_US
dc.typeArticleen_US

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