Expressions of putative cancer stem cell markers, CD44 and CD133, are correlated with pathological tumour stage in gastric adenocarcinoma

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dc.authorid0000-0002-6553-4500
dc.authorid0000-0001-6768-1275
dc.authorid0000-0003-4096-4261
dc.contributor.authorDüzcü, Selma Erdoğan
dc.contributor.authorAstarcı, Hesna Müzeyyen
dc.contributor.authorTunç, Nur
dc.contributor.authorÇetin, Boran
dc.date.accessioned2023-05-24T13:21:35Z
dc.date.available2023-05-24T13:21:35Z
dc.date.issued2021en_US
dc.departmentBAİBÜ, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümüen_US
dc.descriptionThis study was supported by Bolu Abant Izzet Baysal University Scientific Research Projects (2018.08.19.1385).en_US
dc.description.abstractObjective: To analyse partial and total gastrectomy specimen in items of immunohistochemical staining of the stem cell CD44 and CD133; and to determine their relationship to pathological stage, other clinicopathological prognostic parameters, and their predictive value. Study Design: Derscriptive study. Place and Duration of Study: Department of Pathology, Bolu Abant Izzet Baysal University, Medical School, Turkey, from 2013 to 2018. Methodology: Eighty-three cases, diagnosed with adenocarcinoma from stomach partial and total gastrectomy slides and blocks, were included in the study. Adenocarcinoma cases, that had received neoadjuvant treatment before gastrectomy, cases diagnosed with lymphoma and other malignancies and cases of resection performed for reasons other than tumours, were excluded. Formalin-fixed and paraffin wax-embedded gastric adenocarcinoma blocks were sliced. CD44 and CD133 were stained onto the slides in a Leica Bond Max staining device in compliance with immunohistochemical staining datasheets. Membranous staining for CD44 and cytoplasmic, membranous or luminal staining for CD133 were evaluated. Mann-Whitney U-test and Kruskal- Wallis test were used for group comparisons. For pairwise comparisons, post-hoc Dunn's tests were used. The results were assessed on the significance level of p < 0.05. The analyses were performed using the Statistical Package for the Social Sciences version 22.0 for Windows (SPSS Inc., Chicago, Illinois, USA). Results: Considering CD44 and CD133 expressions in terms of pathological stage, there was significantly more intense expression in the T3 and T4 cases (p=0.009, and p=0.002, respectively). Conclusion: Although CD44 is regarded to be associated with more prognostic parameters compared to CD133, both immunohistochemical stains were shown to be related to pathological stage. Thus, these may be guiding for determining the tumour depth.en_US
dc.description.sponsorshipBolu Abant Izzet Baysal University Scientific Research Projects [2018.08.19.1385]en_US
dc.identifier.citationDuzcu, S., ASTARCI, H., Tunc, N., & Boran, C. (2021). Expressions of putative cancer stem cell markers, CD44 and CD133, are correlated with pathological tumour stage in gastric adenocarcinoma. Journal of the College of Physicians and Surgeons Pakistan, 31(5).en_US
dc.identifier.doi10.29271/jcpsp.2021.05.553
dc.identifier.endpage558en_US
dc.identifier.issn1022-386X
dc.identifier.issn1681-7168
dc.identifier.issue5en_US
dc.identifier.pmid34027868en_US
dc.identifier.scopus2-s2.0-85107081837en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage553en_US
dc.identifier.urihttp://dx.doi.org/10.29271/jcpsp.2021.05.553
dc.identifier.urihttps://hdl.handle.net/20.500.12491/10946
dc.identifier.volume31en_US
dc.identifier.wosWOS:000648580000013en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorDüzcü, Selma Erdoğan
dc.institutionauthorAstarcı, Hesna Müzeyyen
dc.institutionauthorTunç, Nur
dc.institutionauthorÇetin, Boran
dc.language.isoenen_US
dc.publisherColl Physicians & Surgeons Pakistanen_US
dc.relation.ispartofJCPSP-Journal of The College Of Physicians and Surgeons Pakistanen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectGastric Adenocarcinomaen_US
dc.subjectCD44en_US
dc.subjectCD133en_US
dc.subjectStem Cell Markeren_US
dc.subjectPrognosisen_US
dc.titleExpressions of putative cancer stem cell markers, CD44 and CD133, are correlated with pathological tumour stage in gastric adenocarcinomaen_US
dc.typeArticleen_US

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