Protective effect of melatonin on beta-cell damage in streptozotocin-induced diabetes in rats

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dc.authorid0000-0003-1937-9244
dc.authorid0000-0002-5800-3306
dc.authorid0000-0003-1691-618X
dc.authorid0000-0001-7511-7105
dc.authorid0000-0001-7191-2240
dc.contributor.authorYavuz, Özlem
dc.contributor.authorCam, Meryem
dc.contributor.authorBukan, Neslihan
dc.contributor.authorGüven, Aysel
dc.contributor.authorSılan, Fatma
dc.date.accessioned2021-06-23T19:17:41Z
dc.date.available2021-06-23T19:17:41Z
dc.date.issued2003
dc.departmentBAİBÜ, Tıp Fakültesi, Temel Tıp Bilimleri Bölümüen_US
dc.description.abstractThe aim of the present study was the evaluation of possible protective effects of melatonin against beta-cell damage in streptozotocin-induced diabetes in rats. Malondialdehyde levels and glutathione peroxidase activity were measured in pancreatic homogenates. Pancreatic beta-cells were examined by immunohistochemical methods. Streptozotocin was injected intraperitoneally at a single dose of 60 mg/kg for induction of diabetes. Melatonin (200 mug/kg/day, ip) was injected for 3 days prior to administration of streptozotocin; these injections were continued until the end of the study (4 weeks). Streptozotocin induced a significant increase in malondialdehyde levels (p < 0.01) and a significant decrease in glutathione peroxidase activity (p < 0.05) in pancreatic tissue. Degeneration of islet cells and weak immunohistochemical staining of insulin was observed in diabetic rats. Treatment of diabetic rats with melatonin markedly reduced malondialdehyde production (p < 0.05) and increased glutathione peroxidase activity (p < 0.01) without affecting hyperglycemia. Increased staining of insulin and preservation of islet cells were apparent in the melatonin-treated diabetic rats. These data suggest that melatonin treatment has a therapeutic effect in diabetes by reduction of oxidative stress and preservation of pancreatic beta-cell integrity.en_US
dc.identifier.doi10.1078/0065-1281-00711
dc.identifier.endpage266en_US
dc.identifier.issn0065-1281
dc.identifier.issue3en_US
dc.identifier.pmid13677620en_US
dc.identifier.scopus2-s2.0-0041877508en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage261en_US
dc.identifier.urihttps://doi.org/10.1078/0065-1281-00711
dc.identifier.urihttps://hdl.handle.net/20.500.12491/5511
dc.identifier.volume105en_US
dc.identifier.wosWOS:000185139500008en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorYavuz, Özlem
dc.institutionauthorCam, Meryem
dc.institutionauthorGüven, Aysel
dc.institutionauthorSılan, Fatma
dc.language.isoenen_US
dc.publisherUrban & Fischer Verlagen_US
dc.relation.ispartofActa Histochemicaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectMelatoninen_US
dc.subjectDiabetes Mellitusen_US
dc.subjectStreptozotocinen_US
dc.subjectOxidative Stressen_US
dc.subjectAnti-insulin Antibodyen_US
dc.titleProtective effect of melatonin on beta-cell damage in streptozotocin-induced diabetes in ratsen_US
dc.typeArticleen_US

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