Methylene blue attenuates renal ischemia-reperfusion injury in rats

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dc.authorid0000-0003-0894-7787en_US
dc.authorid0000-0002-5982-6582en_US
dc.authorid0000-0001-8967-2708
dc.authorid0000-0002-4552-0048
dc.contributor.authorSaraç, Fatma
dc.contributor.authorKılınçaslan, Hüseyin
dc.contributor.authorKılıç, Elif
dc.contributor.authorKoldaş, Macit
dc.contributor.authorTerzi, Elçin Hakan
dc.date.accessioned2021-06-23T19:42:04Z
dc.date.available2021-06-23T19:42:04Z
dc.date.issued2015
dc.departmentBAİBÜ, Tıp Fakültesi, Temel Tıp Bilimleri Bölümüen_US
dc.description.abstractBackground and purpose: In our study, we investigated the effects of methylene blue (MB) on histopathological changes in renal ischemia/reperfusion (I/R) injury rat model. Material and methods: Twenty-one Sprague-Dawley male rats were divided equally into three groups. Group 1 (control) was administered intraperitoneal saline solution. In Groups 2 (untreated group) and 3 (MB treatment), the renal arteries were clamped, and ischemia (for 1 hour) and then reperfusion (for 4 hours) were applied. Thirty minutes before ischemia, the untreated group received physiological saline, whereas the treatment group was administered 30 mg/kg MB through an intraperitoneal route. Blood samples were drawn, and renal specimens were harvested 5.5 hours after physiologic saline injection in the control and immediately after the reperfusion period in the other groups. The levels of tissue superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), total oxidant status (TOS), total antioxidant status (TAS), plasma urea, creatinine and ischemia modified albumin (IMA) were measured. Moreover, the histopathological damage score of the renal tissue was determined. Results: MB significantly alleviated the severity of histopathological damage by increasing the levels of tissue SOD and TAS and decreasing TOS concentrations in the renal I/R model (p < 0.05). Conclusion: Administration of MB in renal I/R damage may play a protective role. (C) 2015 Elsevier Inc. All rights reserved.en_US
dc.identifier.doi10.1016/j.jpedsurg.2014.06.018
dc.identifier.endpage1071en_US
dc.identifier.issn0022-3468
dc.identifier.issn1531-5037
dc.identifier.issue6en_US
dc.identifier.pmid25783339en_US
dc.identifier.scopus2-s2.0-84929346815en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage1067en_US
dc.identifier.urihttps://doi.org/10.1016/j.jpedsurg.2014.06.018
dc.identifier.urihttps://hdl.handle.net/20.500.12491/8324
dc.identifier.volume50en_US
dc.identifier.wosWOS:000354551700039en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorTerzi, Elçin Hakan
dc.language.isoenen_US
dc.publisherW B Saunders Co-Elsevier Incen_US
dc.relation.ispartofJournal Of Pediatric Surgeryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectMethylene Blueen_US
dc.subjectRenal Ischemia/reperfusionen_US
dc.subjectAntioxidanten_US
dc.subjectIschemia Modified Albuminen_US
dc.titleMethylene blue attenuates renal ischemia-reperfusion injury in ratsen_US
dc.typeArticleen_US

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