Anti-inflammatory effect of rosuvastatin decreases alveolar bone loss in experimental periodontitis

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dc.authorid0000-0002-5240-4504
dc.authorid0000-0001-8105-9482
dc.authorid0000-0001-9011-1377
dc.authorid0000-0002-1835-1082
dc.contributor.authorKırzıoğlu, Fatma Yeşim
dc.contributor.authorBulut, Memduha Tözüm
dc.contributor.authorDoğan, Burak
dc.contributor.authorFentoğlu, Özlem
dc.contributor.authorÖzmen, Özlem
dc.contributor.authorÖzdem, Muhsin
dc.date.accessioned2021-06-23T19:48:52Z
dc.date.available2021-06-23T19:48:52Z
dc.date.issued2017
dc.departmentBAİBÜ, Diş Hekimliği Fakültesi, Periodontoloji Ana Bilim Dalıen_US
dc.description.abstractThe effects of systemically administered rosuvastatin on alveolar bone loss (ABL), cytokine levels and oxidative status were investigated in rats with ligature-induced periodontitis. Rats were divided randomly into four groups: a non-ligated group (C); a non-ligated+rosuvastatin group (R); a ligated group (P); and a ligated+rosuvastatin group (PR). Ligatures were placed at the maxillary second molars, and rosuvastatin was administered for 14 days. After the rats had been euthanatized, histomorphometric and histological analyses were performed, and the serum levels of interleukin (IL)-10, IL-10 and oxidant and antioxidant parameters (malondialdehyde [MDA], superoxide dismutase, glutathione, and glutathione peroxidase) were evaluted by enzyme-linked immunosorbent assay. Rosuvastatin significantly decreased the extent of ABL, inflammatory infiltration and osteoclasts in periodontitis, but increased the numbers of osteoblasts. Although rosuvastatin reduced the levels of IL-1 beta, they did not differ significantly between the PR and P groups. In the PR group, not only were IL-10 levels significantly higher but also the ratio of IL-1 beta to IL-10 was lower than in the P group. Although MDA levels were significantly increased in the P group relative to the C group, they did not differ significantly between the PR and C groups. The present data suggest that rosuvastatin decreases ABL in ligature-induced periodontitis, and that its anti-inflammatory effect is more remarkable than its antioxidant effect.en_US
dc.identifier.doi10.2334/josnusd.16-0398
dc.identifier.endpage255en_US
dc.identifier.issn1343-4934
dc.identifier.issn1880-4926
dc.identifier.issue2en_US
dc.identifier.pmid28637984en_US
dc.identifier.scopus2-s2.0-85021170065en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage247en_US
dc.identifier.urihttps://doi.org/10.2334/josnusd.16-0398
dc.identifier.urihttps://hdl.handle.net/20.500.12491/9224
dc.identifier.volume59en_US
dc.identifier.wosWOS:000404096500013en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorÖzdem, Muhsin
dc.language.isoenen_US
dc.publisherNihon Univ, School Dentistryen_US
dc.relation.ispartofJournal Of Oral Scienceen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectRosuvastatinen_US
dc.subjectAlveolar Bone Lossen_US
dc.subjectInterleukinen_US
dc.subjectInterleukin 10en_US
dc.subjectOxidative Stressen_US
dc.subjectPeriodontitisen_US
dc.titleAnti-inflammatory effect of rosuvastatin decreases alveolar bone loss in experimental periodontitisen_US
dc.typeArticleen_US

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