Penicillin-induced epileptiform ECoG activity in gerbils: effects of physical exercise and a Diospyros kaki extract

dc.authorid0000-0002-8212-7149en_US
dc.authorid0000-0002-0000-3768en_US
dc.authorid0000-0001-7712-2813en_US
dc.authorid0000-0003-2701-3250
dc.authorid0000-0003-2784-2980
dc.authorid0000-0003-0390-8164
dc.authorid0000-0002-3499-4088
dc.authorid0000-0002-6817-4512
dc.contributor.authorKayacan, Yıldırım
dc.contributor.authorBahadır, Anzel
dc.contributor.authorÇetinkaya, Ayhan
dc.contributor.authorSoytürk Orallar, Hayriye
dc.contributor.authorÇakır, Serkan
dc.contributor.authorBeyazçiçek, Ersin
dc.contributor.authorÖnal, Cansu
dc.contributor.authorYıldırım, Arzu
dc.date.accessioned2021-06-23T19:42:56Z
dc.date.available2021-06-23T19:42:56Z
dc.date.issued2016
dc.departmentBAİBÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.departmentBAİBÜ, Ziraat Fakültesi, Kanatlı Hayvan Yetiştiriciliği Bölümü
dc.departmentBAİBÜ, Ziraat Fakültesi, Tarla Bitkileri Bölümü
dc.description.abstractMongolian gerbils (28 males) were divided into four groups, control (C), treadmill-exercised (Ex), treated with the extract of Diospyros kaki (Dk), and exercised plus treated with the Dk extract (Ex+Dk). Animals of the respective groups were running-exercised for 30 min per day during 8 weeks, and the Dk extract (dose 20 mg/kg) was given by gavage during five days per week within the same period. After the treatment and exercise period, an epilepsy model was produced by penicillin G injection (500 IU) into the left somatomotor cortex, and the electrocorticogram (ECoG) was recorded during 120 min. The mean frequency of spike/wave complexes was significantly smaller in the Ex and Ex+Dk groups from the 65th min of the observation period and, in the Dk group, from the 75th min than the respective value in the C group (P < 0.01, P < 0.05, and P < 0.01, respectively). The differences in the amplitude values and latency to onset of the spike/wave events among all groups did not reach the significance level (P > 0.05). Thus, both the running exercise and Dk extract applications inhibit penicillin-induced epileptiform activity by altering the spike/wave frequency or severity of seizures observed in ECoG recordings. Further studies are needed to determine the effects of physical activity of different intensities and forms and to analyze the active compounds in the Dk extract.en_US
dc.identifier.doi10.1007/s11062-017-9611-4
dc.identifier.endpage374en_US
dc.identifier.issn0090-2977
dc.identifier.issn1573-9007
dc.identifier.issue5en_US
dc.identifier.scopus2-s2.0-85016424055en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage367en_US
dc.identifier.urihttps://doi.org/10.1007/s11062-017-9611-4
dc.identifier.urihttps://hdl.handle.net/20.500.12491/8645
dc.identifier.volume48en_US
dc.identifier.wosWOS:000398196700007en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.institutionauthorSoytürk Orallar, Hayriye
dc.institutionauthorÇakır, Serkan
dc.institutionauthorÖnal, Cansu
dc.institutionauthorYıldırım, Arzu
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofNeurophysiologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectPhysical Treadmill Exerciseen_US
dc.subjectDiospyros Kaki (Dk)en_US
dc.subjectPenicillin-Induced Epileptiform Activityen_US
dc.subjectElectrocorticography (ECoG)en_US
dc.subjectGerbilsen_US
dc.titlePenicillin-induced epileptiform ECoG activity in gerbils: effects of physical exercise and a Diospyros kaki extracten_US
dc.typeArticleen_US

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