Serum uric acid to HDL-cholesterol ratio is a strong predictor of metabolic syndrome in type 2 diabetes mellitus

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dc.authorid0000-0001-7306-5233en_US
dc.authorid0000-0003-2399-9585en_US
dc.authorid0000-0003-4201-9757en_US
dc.authorid0000-0003-3085-7964en_US
dc.authorid0000-0002-3836-2125en_US
dc.contributor.authorKoçak, Mehmet Zahid
dc.contributor.authorAktaş, Gülali
dc.contributor.authorErkuş, Edip
dc.contributor.authorSincer, İsa
dc.contributor.authorAtak, Burçin
dc.contributor.authorDuman, Tuba Taslamacıoğlu
dc.date.accessioned2021-06-23T19:52:50Z
dc.date.available2021-06-23T19:52:50Z
dc.date.issued2019
dc.departmentBAİBÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.description.abstractOBJECTIVE: Metabolic syndrome (MS) is a clinical entity that associated with increased risk of type 2 Diabetes Mellitus (DM) and cardiovascular diseases. Serum uric acid levels are correlated MS criteria. We hypothesized whether a uric acid to HDL-cholesterol ratio (UHR) could predict diabetic regulation and presence of MS in type 2 diabetic subjects. METHODS: Admissions of the subjects with type 2 DM to outpatient clinics of our institution were retrospectively analyzed. Study population grouped into well-controlled and poorly controlled diabetics according to the HbA1c level (cut off 7%) and further grouped into type 2 DM with and without MS according to the presence of MS. UHR of study groups compared. RESULTS: A hundred diabetic subjects enrolled. Mean UHR was significantly lower in well-controlled diabetics (9.7 +/- 3.7%) compared to poorly controlled subjects (14 +/- 5.4%)(p<0.001). Median UHR of diabetics with MS (13 (6-29) %) was greater than that of the diabetics without MS (9 (3-16) %) (p<0.001). UHR greater than 71% has 77% sensitivity and 60% specifity in predicting worse diabetic control (AUC: 0.752, p<0.001) and a UHR greater than 10.6% has 83% sensitivity and 71% specifity in predicting MS (AUC: 0.839, p<0.001). Sensitivity and specifity of UHR in predicting MS were better than most of the sensitivities and specifities of the five criteria of MS. CONCLUSION: We suggest utilization of UHR in diagnosis of MS as a novel criteria. Nevertheless, prospective studies with larger population may make a better scientific evidence in that issue.en_US
dc.identifier.doi10.1590/1806-9282.65.1.9
dc.identifier.endpage15en_US
dc.identifier.issn1806-9282
dc.identifier.issue1en_US
dc.identifier.pmid30758414en_US
dc.identifier.scopus2-s2.0-85061495219en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage9en_US
dc.identifier.urihttps://doi.org/10.1590/1806-9282.65.1.9
dc.identifier.urihttps://hdl.handle.net/20.500.12491/10213
dc.identifier.volume65en_US
dc.identifier.wosWOS:000458029400003en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorDuman, Tuba Taslamacıoğlu
dc.institutionauthorSincer, İsa
dc.institutionauthorKoçak, Mehmet Zahid
dc.institutionauthorAktaş, Gülali
dc.language.isoenen_US
dc.publisherAssoc Medica Brasileiraen_US
dc.relation.ispartofRevista Da Associacao Medica Brasileiraen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectMetabolic Syndromeen_US
dc.subjectDiabetes Mellitus, type 2en_US
dc.subjectUric Aciden_US
dc.subjectHDL-cholesterolen_US
dc.titleSerum uric acid to HDL-cholesterol ratio is a strong predictor of metabolic syndrome in type 2 diabetes mellitusen_US
dc.typeArticleen_US

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