Sugar based biopolymers in nanomedicine; new emerging era for cancer imaging and therapy

dc.authorid0000-0003-1956-4474en_US
dc.authorid0000-0001-6054-8842en_US
dc.authorid0000-0002-2909-689Xen_US
dc.authorid0000-0003-0742-6162
dc.contributor.authorEroğlu, Mehmet Sayıp
dc.contributor.authorÖner, Ebru Toksoy
dc.contributor.authorMutlu, Esra Cansever
dc.contributor.authorBostan, Müge Sennaroğlu
dc.date.accessioned2021-06-23T19:49:13Z
dc.date.available2021-06-23T19:49:13Z
dc.date.issued2017
dc.departmentBAİBÜ, Rektörlük, Bilimsel Endüstriyel ve Teknolojik Uygulama ve Araştırma Merkezien_US
dc.description.abstractSince last decade, sugar based biopolymers are recognized in nanomedicine as promising materials for cancer imaging and therapy. Their durable, biocompatible and adhesive properties enable the fine tuning of their molecular weights (MW) and their miscellaneous nature makes the molecules acquire various conformations. These in turn provide effective endocytosis by cancer cell membranes that have already been programmed for internalization of different kinds of sugars. Therefore, biocompatible sugar based nanoparticles (SBNPs) are suitable for both cell-selective delivery of drugs and imaging through the human body. Recently, well known sugar-based markers have displayed superior performance to overcome tumor metastasis. Thereby, targeting strategies for cancer cells have been broadened to sugar-based markers as noticed in various clinic phases. In these studies, biopolymers such as chitosan, hyaluronic acid, mannan, dextran, levan, pectin, cyclodextrin, chondroitin sulphate, alginates, amylose and heparin are chemically functionalized and structurally designed as new biocompatible nanoparticles (NPs). The future cancer treatment strategies will mainly comprise of these multifunctional sugar based nanoparticles which combine the therapeutic agents with imaging technologies with the aim of rapid monitoring response to therapies. While each individual imaging and treatment step requires a long time period in effective treatment of diseases, these multifunctional sugar based nanoparticles will have the advantage of rapid detection, right drug efficiency evaluation and immediate interfere opportunity to some important diseases, especially rapidly progressing cancers. In this article, we evaluated synthesis, characterization and applications of main sugar based biopolymers and discussed their great promise in nano-formulations for cancer imaging and therapy. However much should be done and optimized prior to clinical applications of these nano-formulations for an efficient drug treatment without overall toxicity for getting most effective clinical results.en_US
dc.identifier.doi10.2174/1568026616666161222101703
dc.identifier.endpage1520en_US
dc.identifier.issn1568-0266
dc.identifier.issn1873-5294
dc.identifier.issue13en_US
dc.identifier.pmid28017156en_US
dc.identifier.scopus2-s2.0-85019572205en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage1507en_US
dc.identifier.urihttps://doi.org/10.2174/1568026616666161222101703
dc.identifier.urihttps://hdl.handle.net/20.500.12491/9417
dc.identifier.volume17en_US
dc.identifier.wosWOS:000399448200005en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorMutlu, Esra Cansever
dc.language.isoenen_US
dc.publisherBentham Science Publ Ltden_US
dc.relation.ispartofCurrent Topics In Medicinal Chemistryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectSugaren_US
dc.subjectBiopolymeren_US
dc.subjectCanceren_US
dc.subjectImagingen_US
dc.subjectNanoparticleen_US
dc.subjectTherapyen_US
dc.titleSugar based biopolymers in nanomedicine; new emerging era for cancer imaging and therapyen_US
dc.typeArticleen_US

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
Küçük Resim Yok
İsim:
mehmet-s-eroglu.pdf
Boyut:
2.37 MB
Biçim:
Adobe Portable Document Format
Açıklama:
Tam Metin/Full Text