The impact of oxytocin on thiol/disulphide and malonyldialdehyde/glutathione homeostasis in stressed rats

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dc.authorid0000-0002-9097-1024en_US
dc.authorid0000-0003-0434-3206en_US
dc.authorid0000-0002-9097-1024
dc.authorid0000-0003-0434-3206
dc.contributor.authorKorkmaz, Hilal
dc.contributor.authorÖnal, Deniz
dc.contributor.authorAlışık, Murat
dc.contributor.authorErel, Özcan
dc.contributor.authorPehlivanoğlu, Bilge
dc.date.accessioned2021-06-23T19:53:53Z
dc.date.available2021-06-23T19:53:53Z
dc.date.issued2020
dc.departmentBAİBÜ, Tıp Fakültesi, Temel Tıp Bilimleri Bölümüen_US
dc.description.abstractWe aimed to investigate the impact of oxytocin on serum thiol/disulphide and malonylyldialdehyde (MDA)/glutathione balance under acute stress (AS) and chronic stress (CS) exposure in rats. Animals were allocated into control (C), AS and CS groups, then the groups subdivided as intranasal oxytocin or saline applied groups, randomly. Animals in the AS or CS groups were exposed to combined cold-immobilisation stress. Salivary corticosterone levels and elevated plus maze (EPM) scores were used to assess stress response. MDA, glutathione, thiol-disulphide levels were measured in the serum samples. Oxytocin treatment attenuated stress response regardless of the stress duration verified by lower corticosterone level and favorable profile in EPM parameters measured. Furthermore, oxytocin modulated oxidant profile suggesting lowered oxidant stress with decreased serum MDA/ glutathione and disulfide/native thiol ratios. Oxytocin improves the response of organism to stress via both its anxiolytic and antioxidant effects. That's why it can be considered as a protective measure to employ methods to increase endogenous oxytocin and/or to apply exogenous oxytocin to prevent stress-induced increase in oxidant stress, which plays a pivotal role in the pathogenesis of various stress-related diseases.en_US
dc.identifier.doi10.1515/hsz-2020-0190
dc.identifier.endpage1292en_US
dc.identifier.issn1431-6730
dc.identifier.issn1437-4315
dc.identifier.issue11en_US
dc.identifier.pmid32554831en_US
dc.identifier.scopus2-s2.0-85090592303en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage1283en_US
dc.identifier.urihttps://doi.org/10.1515/hsz-2020-0190
dc.identifier.urihttps://hdl.handle.net/20.500.12491/10313
dc.identifier.volume401en_US
dc.identifier.wosWOS:000581066400007en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorAlışık, Murat
dc.language.isoenen_US
dc.publisherWalter De Gruyter Gmbhen_US
dc.relation.ispartofBiological Chemistryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAcute Stressen_US
dc.subjectChronic Stressen_US
dc.subjectGSHen_US
dc.subjectMDAen_US
dc.subjectOxytocinen_US
dc.subjectThiolen_US
dc.titleThe impact of oxytocin on thiol/disulphide and malonyldialdehyde/glutathione homeostasis in stressed ratsen_US
dc.typeArticleen_US

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