Clinical and cytogenetic results of a large series of amniocentesis cases from Turkey: report of 6124 cases

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dc.contributor.authorOcak, Zeynep
dc.contributor.authorÖzlü, Tülay
dc.contributor.authorYazıcıoğlu, Hasan Fehmi
dc.contributor.authorÖzyurt, Osman
dc.contributor.authorAygün, Mehmet
dc.date.accessioned2021-06-23T19:37:00Z
dc.date.available2021-06-23T19:37:00Z
dc.date.issued2014
dc.departmentBAİBÜ, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümüen_US
dc.description.abstractAimThe aim of this study was to document the clinical and cytogenetic results of a large series of amniocentesis (AS) cases from Turkey. Material and MethodsSecond-trimester amniocentesis cases performed in Suleymaniye Maternity Hospital for Research and Training between January 2007 and December 2011 were included. ResultsDuring this period, 6124 AS were performed. Indications were increased risk in maternal serum screening (MSS) (56%), advanced maternal age (29%) and pathologic ultrasound finding (11.5%). Most frequent MSS abnormality was abnormal triple test result (58%). Overall culture success rate was 98.8%. Chromosomal abnormality was detected in 215 (3.6%) of the 6052 cytogenetic results (74.9% numerical, 25.1% structural). Most frequent numerical chromosomal abnormality was trisomy 21 (61.9%). Clinically insignificant polymorphisms were the most frequent structural changes (n=571). Most frequent polymorphism was increase in heterochromatin region in the 1st chromosome (n=158). Advanced maternal age had a positive predictive value of 5.2%. Among the MSS tests, the combined test had the highest positive predictive value (5.2%). ConclusionsIn our study, abnormal MSS (and among these, abnormal triple test result) was the most frequent indication for amniocentesis. Our overall culture success rate was 98.8%. Frequency of major chromosomal abnormality was 3.2% and trisomy 21 was the most frequent abnormality.en_US
dc.identifier.doi10.1111/jog.12144
dc.identifier.endpage146en_US
dc.identifier.issn1341-8076
dc.identifier.issn1447-0756
dc.identifier.issue1en_US
dc.identifier.pmid24033845en_US
dc.identifier.scopus2-s2.0-84897071008en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage139en_US
dc.identifier.urihttps://doi.org/10.1111/jog.12144
dc.identifier.urihttps://hdl.handle.net/20.500.12491/8091
dc.identifier.volume40en_US
dc.identifier.wosWOS:000329141700020en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorÖzlü, Tülay
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofJournal Of Obstetrics And Gynaecology Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAmniocentesisen_US
dc.subjectChromosomal Abnormalityen_US
dc.subjectDown Syndromeen_US
dc.subjectPrenatal Diagnosisen_US
dc.titleClinical and cytogenetic results of a large series of amniocentesis cases from Turkey: report of 6124 casesen_US
dc.typeArticleen_US

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