Increased visfatin and leptin in pregnancies complicated by pre-eclampsia

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dc.authorid0000-0002-5344-9739en_US
dc.authorid0000-0002-4060-3354en_US
dc.contributor.authorAdalı, Ertan
dc.contributor.authorYıldızhan, Recep
dc.contributor.authorKolusarı, Ali
dc.contributor.authorKurdoğlu, Mertihan
dc.contributor.authorBuğdaycı, Güler
dc.contributor.authorŞahin, Hanım Güler
dc.contributor.authorKamacı, Mansur
dc.date.accessioned2021-06-23T19:26:32Z
dc.date.available2021-06-23T19:26:32Z
dc.date.issued2009
dc.departmentBAİBÜ, Tıp Fakültesi, Temel Tıp Bilimleri Bölümüen_US
dc.description.abstractObjective. To evaluate the role of the adipokines, visfatin and leptin in the pathophysiology of pre-eclampsia and how their concentrations correlate with the severity of the disease and abnormal Doppler velocimetry. Methods. A cross-sectional study was carried out in 72 pregnant women (30 patients with mild pre-eclampsia, 20 patients with severe pre-eclampsia and 22 healthy normotensive pregnant women) during the third trimester of pregnancy. The maternal levels of plasma visfatin and serum leptin were determined in all cases by enzyme immunoassay and enzyme-linked immunosorbent assay, respectively. The uterine artery and umbilical artery RI were determined by Doppler analysis in all cases. Results. Plasma visfatin levels and serum leptin levels were higher in patients with pre-eclampsia than in the normotensive pregnant women. Six patients with mild pre-eclampsia and five patients with severe pre-eclampsia had abnormal Doppler velocimetry. Visfatin and leptin levels of pre-eclamptic patients with abnormal Doppler velocimetry were significantly higher than they were in those with normal Doppler velocimetry. Serum leptin levels were positively correlated with plasma visfatin level in cases of pre-eclampsia. Conclusions. These findings suggest that increased maternal levels of leptin and visfatin may be involved in the pathogenesis of pre-eclampsia, and measurement of these adipokines may be useful in assessment of the severity of disease.en_US
dc.identifier.doi10.1080/14767050902994622
dc.identifier.endpage879en_US
dc.identifier.issn1476-7058
dc.identifier.issn1476-4954
dc.identifier.issue10en_US
dc.identifier.pmid19488934en_US
dc.identifier.scopus2-s2.0-70350680998en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage873en_US
dc.identifier.urihttps://doi.org/10.1080/14767050902994622
dc.identifier.urihttps://hdl.handle.net/20.500.12491/6580
dc.identifier.volume22en_US
dc.identifier.wosWOS:000270938600010en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorBuğdaycı, Güler
dc.language.isoenen_US
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofJournal Of Maternal-Fetal & Neonatal Medicineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectPre-eclampsiaen_US
dc.subjectVisfatinen_US
dc.subjectLeptinen_US
dc.subjectDoppleren_US
dc.subjectAdipokinesen_US
dc.titleIncreased visfatin and leptin in pregnancies complicated by pre-eclampsiaen_US
dc.typeArticleen_US

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