Immunolocalization of TGF-beta 2 in the rat thymus during late stages of prenatal development

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dc.authorid0000-0001-7210-6873en_US
dc.authorid0000-0003-1364-4684
dc.contributor.authorSönmez, Mehmet Fatih
dc.contributor.authorÇolakoğlu, Neriman
dc.contributor.authorKükner, Aysel
dc.contributor.authorOzan, Enver
dc.contributor.authorDabak, Dürrin Özlem
dc.date.accessioned2021-06-23T19:26:26Z
dc.date.available2021-06-23T19:26:26Z
dc.date.issued2009
dc.departmentBAİBÜ, Tıp Fakültesi, Temel Tıp Bilimleri Bölümüen_US
dc.description.abstractThe aim of this study was to investigate the immunolocalization of transforming growth factor beta (TGF-beta 2) in rat thymic stromal cells and thymocytes and investigate the roles of TGF-beta 2 in thymopoiesis during the late stages of fetal development. Twelve adult pregnant female Wistar rats weighing 250-270g were used in this study. The rats were killed by cervical dislocation on gestation days 16 (GD 16), 18 (GD18) and 20 (GD20). Fetal thymus glands were prepared and examined by an immunohistochemical technique to reveal binding of an anti-TGF-beta 2 rabbit polyclonal antibody. The thymic primordium was surrounded with a connective tissue capsule at GD16 and at this stage TGF-beta 2 immunoreactivity was not observed. At GD18, the connective tissue capsule had formed septa which subdivided the tissue into lobules and at this stage TGF-beta 2 immunolocalization was detected in the capsule and in thymocytes. Lobulation was more evident at GD20 and TGF-beta 2 immunoreactivity of thymocytes was more extensive than on GD18. Results indicate that TGF-beta 2 may play an important role in the organization or development of thymocytes in the late stages of thymopoiesis. (C) 2008 Elsevier GmbH. All rights reserved.en_US
dc.identifier.doi10.1016/j.acthis.2008.04.003
dc.identifier.endpage73en_US
dc.identifier.issn0065-1281
dc.identifier.issn1618-0372
dc.identifier.issue1en_US
dc.identifier.pmid18554691en_US
dc.identifier.scopus2-s2.0-57649198452en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage68en_US
dc.identifier.urihttps://doi.org/10.1016/j.acthis.2008.04.003
dc.identifier.urihttps://hdl.handle.net/20.500.12491/6546
dc.identifier.volume111en_US
dc.identifier.wosWOS:000262920300009en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorKükner, Aysel
dc.language.isoenen_US
dc.publisherElsevier Gmbhen_US
dc.relation.ispartofActa Histochemicaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectTGF-beta 2en_US
dc.subjectThymopoiesisen_US
dc.subjectPrenatal Developmenten_US
dc.subjectThymusen_US
dc.subjectRaten_US
dc.titleImmunolocalization of TGF-beta 2 in the rat thymus during late stages of prenatal developmenten_US
dc.typeArticleen_US

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