Beneficial effect of dexmedetomidine on testicular ischemia - reperfusion injury in rats
Küçük Resim Yok
Tarih
2008
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Wroclaw Medical University
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Background/Objectives. The present study was designed to determine the beneficial effect of dexmedetomidine (Dex) on torsion-detorsion-induced histopathological changes in experimental testicular ischemia/reperfusion (I-R) injury in rats. Material and Methods. Twenty-one male Sprague-Dawley rats were separated into three groups of seven rats each. A sham operation was performed in group 1 (control). In group 2 (I-R/Untreated), unilateral testicular torsion was performed for 6 h followed by 1 h of detorsion of the testis. In group 3 (I-R/Dex), after performing the same procedures as in group 2, dexmedetomidine was given intravenously. Ipsilateral orchidectomies were performed in all experimental rats for histological examination. The levels of MDA and activities of SOD and CAT were measured in the testicular tissue. Results. MDA levels were higher in group 2 than in group 1 rats and lower in group 3 than in group 2. SOD and CAT activities were higher in group 3 than in group 2 rats. Histopathologically, in the group 2 rats the lesions varied between grades III and IV and edema, congestion, hemorrhage between seminiferous tubules, and necrosis of the germinal cells were predominant features in sections. However, most of the specimens in the dexmedetomi-dine-treated group 3 showed grades I and II injury. The testicular injury score was also lower in group 3 rats than in group 2. Conclusions. The results show that dexmedetomidine may play a protective role in reducing injury caused by I-R (Adv Clin Exp Med 2008, 17, 5, 513-518).
Açıklama
Anahtar Kelimeler
Testicular Torsion, Ischemia-reperfusion, Dexmedetomidine, Rat
Kaynak
Advances In Clinical And Experimental Medicine
WoS Q Değeri
N/A
Scopus Q Değeri
Q1
Cilt
17
Sayı
5
Künye
Bağlantı
https://hdl.handle.net/20.500.12491/6333
https://www.scopus.com/record/display.uri?eid=2-s2.0-57649242571&origin=resultslist&sort=plf-f&src=s&st1=Beneficial+Effect+of+Dexmedetomidine+on+Testicular+Ischemia+-+Reperfusion+Injury+in+Rats&sid=7bada28138094ca231faf07889a8731e&sot=b&sdt=b&sl=103&s=TITLE-ABS-KEY%28Beneficial+Effect+of+Dexmedetomidine+on+Testicular+Ischemia+-+Reperfusion+Injury+in+Rats%29&relpos=0&citeCnt=1&searchTerm=&featureToggles=FEATURE_NEW_DOC_DETAILS_EXPORT:1
https://www.scopus.com/record/display.uri?eid=2-s2.0-57649242571&origin=resultslist&sort=plf-f&src=s&st1=Beneficial+Effect+of+Dexmedetomidine+on+Testicular+Ischemia+-+Reperfusion+Injury+in+Rats&sid=7bada28138094ca231faf07889a8731e&sot=b&sdt=b&sl=103&s=TITLE-ABS-KEY%28Beneficial+Effect+of+Dexmedetomidine+on+Testicular+Ischemia+-+Reperfusion+Injury+in+Rats%29&relpos=0&citeCnt=1&searchTerm=&featureToggles=FEATURE_NEW_DOC_DETAILS_EXPORT:1
