Recent developments in therapeutic protein expression technologies in plants

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dc.authorid0000-0001-6767-2539en_US
dc.authorid0000-0002-3217-9688en_US
dc.contributor.authorFahad, Shah
dc.contributor.authorKhan, Faheem Ahmed
dc.contributor.authorPandupuspitasari, Nuruliarizki Shinta
dc.contributor.authorAhmed, Muhammad Mahmood
dc.contributor.authorLiao, Yu Cai
dc.contributor.authorSameeullah, Muhammad
dc.date.accessioned2021-06-23T19:42:22Z
dc.date.available2021-06-23T19:42:22Z
dc.date.issued2015
dc.departmentBAİBÜ, Fen Edebiyat Fakültesi, Biyoloji Bölümüen_US
dc.description.abstractInfectious diseases and cancers are some of the commonest causes of deaths throughout the world. The previous two decades have witnessed a combined endeavor across various biological sciences to address this issue in novel ways. The advent of recombinant DNA technologies has provided the tools for producing recombinant proteins that can be used as therapeutic agents. A number of expression systems have been developed for the production of pharmaceutical products. Recently, advances have been made using plants as bioreactors to produce therapeutic proteins directed against infectious diseases and cancers. This review highlights the recent progress in therapeutic protein expression in plants (stable and transient), the factors affecting heterologous protein expression, vector systems and recent developments in existing technologies and steps towards the industrial production of plant-made vaccines, antibodies, and biopharmaceuticals.en_US
dc.identifier.doi10.1007/s10529-014-1699-7
dc.identifier.endpage279en_US
dc.identifier.issn0141-5492
dc.identifier.issn1573-6776
dc.identifier.issue2en_US
dc.identifier.pmid25326175en_US
dc.identifier.scopus2-s2.0-84925518115en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage265en_US
dc.identifier.urihttps://doi.org/10.1007/s10529-014-1699-7
dc.identifier.urihttps://hdl.handle.net/20.500.12491/8457
dc.identifier.volume37en_US
dc.identifier.wosWOS:000349230800003en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorSameeullah, Muhammad
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofBiotechnology Lettersen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAntibodiesen_US
dc.subjectBacterial Cellsen_US
dc.subjectBiopharmaceuticalsen_US
dc.subjectMammalian Cellsen_US
dc.subjectProtein Expressionen_US
dc.subjectVaccinesen_US
dc.titleRecent developments in therapeutic protein expression technologies in plantsen_US
dc.typeReview Articleen_US

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