A multicentre prospective analysis of the incidence of pemphigoid diseases in Turkey
Yükleniyor...
Dosyalar
Tarih
2021
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Wiley
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Background:The differentiation between thepemphigoid diseases is essential for treatment andprognosis. In Turkey, data on the incidence of thesediseases are insufficient. Our aim in this study is todetermine the incidence, demographics and clinicalcharacteristics associated with diseases of the pem-phigoid group.Methods:We prospectively analysed 295 patientswith pemphigoid who visited dermatology clinics oftertiary referral hospitals in 12 different regions ofTurkey within a year. The diagnosis was based onclinical, histopathological, direct immunofluores-cence (DIF) and serological (multivariant enzyme-linked immunosorbent assay [ELISA], indirectimmunofluorescence and mosaic-based BIOCHIP)examinations. Clinical and demographicfindings,aetiological factors and concomitant diseasesobserved in the patients were recorded.Results:A total of 295 (female/male ratio: 1.7/1)patients with pemphigoid were diagnosed in 1-yearperiod. The overall incidence rate of pemphigoiddiseases was found to be 3.55 cases per million-years. The ratio of pemphigoid group diseases topemphigus group diseases was 1.6. The most com-mon pemphigoid type was bullous pemphigoid (BP,93.2%). The others were epidermolysis bullosaacquisita (3.1%), pemphigoid gestationis (2.4%), lin-ear IgA disease (1%) and mucous membrane pem-phigoid (0.3%). The most common (26.8%) possibletrigger of the bullous pemphigoid was gliptin deriva-tive drugs. The most common concomitant diseaseswith pemphigoid were cardiovascular (27.8%) andneurological diseases (23.7%).Conclusions:This study showed that the increasedfrequency of bullous pemphigoid reversed the pem-phigoid/pemphigus ratio in Turkey. Further studiesare warranted regarding the reasons for this increase.Key words: Bullous pemphigoid, acquired epider-molysis bullosa, benign mucous membrane pem-phigoid, pemphigoid gestationis, incidence study.
Açıklama
Anahtar Kelimeler
Bullous Pemphigoid, Acquired Epidermolysis Bullosa, Benign Mucous Membrane Pemphigoid, Pemphigoid Gestationis, Incidence Study
Kaynak
Australasian Journal of Dermatology
WoS Q Değeri
Q3
Scopus Q Değeri
Q2
Cilt
62
Sayı
4
Künye
Durdu, M., Bozca, B. C., Enli, S., Yazıcı Özgen, Z., Yaylı, S., Aktan, Ş., ... & Uzun, S. (2021). A multicentre prospective analysis of the incidence of pemphigoid diseases in Turkey. Australasian Journal of Dermatology, 62(4), e496-e503.
