Programmed cell death ligand 1 expression level and prognostic significance in acute myeloid leukemia

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dc.authorid0000-0001-9556-8915en_US
dc.authorid0000-0002-2596-4493en_US
dc.authorid0000-0002-5603-1178en_US
dc.authorid0000-0001-7083-9379en_US
dc.authorid0000-0002-4303-9488en_US
dc.authorid0000-0003-0851-3583en_US
dc.contributor.authorGedük, Ayfer
dc.contributor.authorAteşoğlu, Elif Birtaş
dc.contributor.authorMehtap, Özgür
dc.contributor.authorDemirsoy, Esra Terzi
dc.contributor.authorMengüç, Meral Uluköylü
dc.contributor.authorTarkun, Pınar
dc.date.accessioned2023-07-12T07:29:00Z
dc.date.available2023-07-12T07:29:00Z
dc.date.issued2022en_US
dc.departmentBAİBÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.description.abstractPurpose: We aimed to evaluate the expression level of programmed death ligand-1 (PD-L1) and its effects on prognosis in acute myeloid leukemia. Methods: The flow cytometry was used to detect PD-L1 expression on leukemic cells of 86 de novo acute myeloid leukemia patients with longitudinal follow-up. Results: Median follow-up was 13 (0-73) months. The mean of expression level was 3.22 +/- 0.47 at diagnosis and ranged from 0 to 28%. PD-L1 expression tended to be lower in patients with acute promyelocytic leukemia (2.47 +/- 1.08, p = 0.09) but there was no significant difference between neither diagnostic nor cytogenetic subgroups. There was no difference in PD-L1 levels between the patients who achieved complete remission (3.4 +/- 0.61) and those who did not (2.91 +/- 0.72, p = 0.94). The patients with low PD-L1 at diagnosis (median 25 mo [95% CI; 0-56.7]) had a longer overall survival compared with high PD-L1 (median 13 mo [95% CI; 5.52-25.17], p = 0.079). PD-L1 expression was lower at relapse (2.04 +/- 0.79) compared to initial diagnosis (4.52 +/- 0.93, p = 0.049). The patients who had overall survival longer than 1 year showed lower PD-L1 expression at relapse (0.66 +/- 0.93) compared with who had not (5.06 +/- 4.28, p = 0.052). A negative correlation between CD33 and PD-L1 (r = - 0.303, p = 0.005) was detected. Conclusion: Despite its low expression levels, PD-L1 appears to be a clinically important prognostic factor. The negative correlation determined between PD-L1 and CD33 supports the combination approach of PD-L1 inhibitors and CD33 targeted immunotherapies.en_US
dc.identifier.citationGeduk, A., Atesoglu, E. B., Mehtap, O., Demirsoy, E. T., Menguc, M. U., Tarkun, P., ... & Balcı, S. (2022). Programmed Cell Death Ligand 1 Expression Level and Prognostic Significance in Acute Myeloid Leukemia. Indian Journal of Hematology and Blood Transfusion, 1-9.en_US
dc.identifier.doi10.1007/s12288-021-01473-2
dc.identifier.endpage472en_US
dc.identifier.issn0971-4502
dc.identifier.issn0974-0449
dc.identifier.issue3en_US
dc.identifier.pmid35747564en_US
dc.identifier.scopus2-s2.0-85111385921en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage464en_US
dc.identifier.urihttp://dx.doi.org/10.1007/s12288-021-01473-2
dc.identifier.urihttps://hdl.handle.net/20.500.12491/11273
dc.identifier.volume38en_US
dc.identifier.wosWOS:000677975300001en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorMengüç, Meral Uluköylü
dc.language.isoenen_US
dc.publisherSpringer Indiaen_US
dc.relation.ispartofIndian Journal of Hematology and Blood Transfusionen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectPD-L1en_US
dc.subjectB7-H1en_US
dc.subjectCD274en_US
dc.subjectImmune Checkpointen_US
dc.subjectFlow Cytometryen_US
dc.titleProgrammed cell death ligand 1 expression level and prognostic significance in acute myeloid leukemiaen_US
dc.typeArticleen_US

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