Memory-enhancing effects of the leptin hormone in Wistar albino rats: sex and generation differences

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dc.authorid0000-0002-5509-8717
dc.contributor.authorKarakaş, Alper
dc.contributor.authorCoşkun, Hamit
dc.contributor.authorKızılkaya, Fevziye Umut
dc.date.accessioned2021-06-23T19:35:04Z
dc.date.available2021-06-23T19:35:04Z
dc.date.issued2013
dc.departmentBAİBÜ, Fen Edebiyat Fakültesi, Biyoloji Bölümüen_US
dc.description.abstractLeptin is a hormone secreted by adipose tissue that informs the brain about the fat stores of the body. In this study, we examined the effects of timed leptin injections on spatial memory performances of adult and juvenile male and female Wistar rats with the Morris water maze test. We applied the injections and conducted the training trials for 4 days. On the fifth day after leptin injections, the experiments were performed. The activities were recorded and analyzed with the Noldus Ethovision Animal Video Tracking System. The results show that the spatial memory performance of the rats was improved by the leptin injections since they shortened the latency to find the platform and elongated the time spent in the correct quadrant. The age of the rats was found to be important since the adults found the platform faster-than the juveniles. There was an interaction effect between sex and generation in all parameters examined except for the time spent in the correct quadrant. The results of the present study suggest that leptin administration via timed injections strengthens spatial memory in Wistar albino rats, but this effect depends upon the sex and the generation of the rats.en_US
dc.identifier.endpage229en_US
dc.identifier.issn1300-0152
dc.identifier.issn1303-6092
dc.identifier.issue2en_US
dc.identifier.scopus2-s2.0-84875515346en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage222en_US
dc.identifier.trdizinid142713en_US
dc.identifier.urihttps://dergipark.org.tr/en/download/article-file/121038
dc.identifier.urihttps://hdl.handle.net/20.500.12491/7701
dc.identifier.volume37en_US
dc.identifier.wosWOS:000321227800014en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.institutionauthorKarakaş, Alper
dc.institutionauthorCoşkun, Hamit
dc.institutionauthorKızılkaya, Fevziye Umut
dc.language.isoenen_US
dc.publisherTubitak Scientific & Technical Research Council Turkeyen_US
dc.relation.ispartofTurkish Journal Of Biologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectLeptinen_US
dc.subjectMorris Water Mazeen_US
dc.subjectSpatial Memoryen_US
dc.titleMemory-enhancing effects of the leptin hormone in Wistar albino rats: sex and generation differencesen_US
dc.typeArticleen_US

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