Does alpha-1-acid glycoprotein determine for infertility in polycystic ovary syndrome?

Objectives: The underlying cause of metabolic abnormalities and ovarian dysfunction in PCOS is thought to chronic low-grade inflammation. This study aimed to show whether alpha-1-acid glycoprotein (AGP), an inflammatory marker, predicts the risk of infertility in fertile and infertile women with PCOS. Our study had a crossectional case-control design. Study design: A total of 20 fertile and 50 infertile patients with PCOS who wanted a child were in the early follicular phase were included in our study. Among the study groups (fertil (n = 20) and infertile (n = 50), AGP, CRP, NLR, BMI, FAI, VAI, triglyceride, HDL-cholesterol, fasting blood sugar, HOMA-IR, SHBG, testosterone values and waist circumference were measured. Results: Among the inflammatory markers compared in the fertile and infertile groups included in the study, only the difference between the AGP variable was statistically significant (p = 0.011). The mean AGP was found to higher at a statistically significant level in the infertile group (p < 0.05). Age, BMI, waist circumference and AGP were weakly positive and CRP was moderately positive in the infertile group (p < 0.05). Conclusion: AGP can be a good indicator of inflammation in PCOS, especially in infertility. Revealing the risk of infertility in PCOS with AGP measurement may contribute to the correct management of the reproductive process.