Does alpha-1-acid glycoprotein determine for infertility in polycystic ovary syndrome?
Yükleniyor...
Dosyalar
Tarih
2022
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Elseiver
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Objectives: The underlying cause of metabolic abnormalities and ovarian dysfunction in PCOS is thought to chronic low-grade inflammation. This study aimed to show whether alpha-1-acid glycoprotein (AGP), an inflammatory marker, predicts the risk of infertility in fertile and infertile women with PCOS. Our study had a crossectional case-control design. Study design: A total of 20 fertile and 50 infertile patients with PCOS who wanted a child were in the early follicular phase were included in our study. Among the study groups (fertil (n = 20) and infertile (n = 50), AGP, CRP, NLR, BMI, FAI, VAI, triglyceride, HDL-cholesterol, fasting blood sugar, HOMA-IR, SHBG, testosterone values and waist circumference were measured. Results: Among the inflammatory markers compared in the fertile and infertile groups included in the study, only the difference between the AGP variable was statistically significant (p = 0.011). The mean AGP was found to higher at a statistically significant level in the infertile group (p < 0.05). Age, BMI, waist circumference and AGP were weakly positive and CRP was moderately positive in the infertile group (p < 0.05). Conclusion: AGP can be a good indicator of inflammation in PCOS, especially in infertility. Revealing the risk of infertility in PCOS with AGP measurement may contribute to the correct management of the reproductive process.
Açıklama
Anahtar Kelimeler
Polycystic Ovary Syndrome, Alpha-1-Acid Glycoprotein, Orosomucoid, Grade Chronic Inflammation, Acute-Phase Protein, C-Reactive Protein
Kaynak
European Journal of Obstetrics & Gynecology and Reproductive Biology
WoS Q Değeri
Q3
Scopus Q Değeri
Cilt
274
Sayı
Künye
Durmuş, M., Uzunlar, Ö., Çelik, H., & Çandar, T. (2022). Does alpha-1-acid glycoprotein determine for infertility in polycystic ovary syndrome?. European Journal of Obstetrics & Gynecology and Reproductive Biology, 274, 155-159.
