Treatment decision plans matter in elderly patients with gastrointestinal cancer: suboptimal or optimal?

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dc.authorid0000-0002-6839-2632
dc.contributor.authorÜyetürk, Ümmügül
dc.contributor.authorTürker, İbrahim
dc.contributor.authorBal, Öznur
dc.contributor.authorDemirci, Ayşe
dc.contributor.authorSönmez, Özlem Uysal
dc.date.accessioned2021-06-23T19:36:04Z
dc.date.available2021-06-23T19:36:04Z
dc.date.issued2014
dc.departmentBAİBÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.description.abstractPurpose: Aging is an important risk factor for cancer. Molecular changes and defective immunity associated with aging result in increased susceptibility to many carcinogens of the gastrointestinal system (GIS). Comorbidities and changes in drug metabolism in elderly patients make the treatment of GIS cancers difficult. Methods: Between January 2009 and December 2012, a total of 790 patients diagnosed with GIS cancers were retrospectively evaluated. Among them, 357 patients aged >= 65 years constituted the study population in which the patient characteristics, disease location, TNM stage, ECOG PS, co-morbidities, chemotherapy regimens and overall survival (OS) were assessed. Results: The patient median age was 71 years (range 65-94). Cancer localizations were colorectal cancer (CRC), gastric cancer, and the pancreaticobiliary system (PBS) cancer in 178 (49.9%), 124 (34.7%), and 55 (15.4%) patients, respectively. A total of 260 (69%) patients underwent chemotherapy: 167 (64.3%) patients received optimal chemotherapy, and 93 (35.7%) suboptimal chemotherapy. The median OS was 47, 14, and 11 months in CRC, gastric, and PBS cancers, respectively. OS was better in the optimally-treated group than in the suboptimally-treated group among patients with all types of cancer. OS was 67 vs 19 months (p<0.001), 17 vs 8 months (p=0.004), and 12 vs 10 months (p=0.46) in CRC, gastric, and PBS cancers in the optimal and suboptimal chemotherapy groups, respectively. Multivariate analysis showed that the disease stage in all cancer types and optimal chemotherapy in the CRC group were important predictors of survival (p<0.001 and p=0.021, respectively). Conclusion: Cancer is usually in advanced stage at the time of diagnosis in these elderly patients and screening programs might improve outcomes in this age group. Patients with GIS cancers (especially CRC and gastric cancer) should be encouraged to receive optimal chemotherapy regimens.en_US
dc.identifier.endpage371en_US
dc.identifier.issn1107-0625
dc.identifier.issn2241-6293
dc.identifier.issue2en_US
dc.identifier.pmid24965393en_US
dc.identifier.scopus2-s2.0-84904201179en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage365en_US
dc.identifier.urihttps://www.jbuon.com/archive/19-2-365.pdf
dc.identifier.urihttps://hdl.handle.net/20.500.12491/7924
dc.identifier.volume19en_US
dc.identifier.wosWOS:000338407700006en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorÜyetürk, Ümmügül
dc.language.isoenen_US
dc.publisherImprimatur Publicationsen_US
dc.relation.ispartofJournal Of Buonen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectElderlyen_US
dc.subjectGastrointestinal System Cancersen_US
dc.subjectSurvivalen_US
dc.subjectTreatmenten_US
dc.titleTreatment decision plans matter in elderly patients with gastrointestinal cancer: suboptimal or optimal?en_US
dc.typeArticleen_US

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