Effect of pregabalin and dexamethasone addition to multimodal analgesia on postoperative analgesia following rhinoplasty surgery

Basit Öğe Kaydı
dc.authorid0000-0002-1630-2033en_US
dc.authorid0000-0002-3060-6420en_US
dc.contributor.authorDemirhan, Abdullah
dc.contributor.authorTekelioğlu, Ümit Yaşar
dc.contributor.authorAkkaya, Akcan
dc.contributor.authorBilgi, Murat
dc.contributor.authorApuhan, Tayfun
dc.contributor.authorKarabekmez, Furkan Erol
dc.contributor.authorBayır, Hakan
dc.contributor.authorKurt, Adem Deniz
dc.contributor.authorKoçoğlu, Hasan
dc.date.accessioned2021-06-23T19:34:07Z
dc.date.available2021-06-23T19:34:07Z
dc.date.issued2013
dc.departmentBAİBÜ, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümüen_US
dc.description.abstractWe investigated the effect of a combination of pregabalin and dexamethasone, when used as part of a multimodal analgesic regimen, on pain control after rhinoplasty operations. Sixty patients were enrolled in this study. They were randomly assigned into three groups: Group C (placebo + placebo), Group P (pregabalin + placebo), and Group PD (pregabalin + dexamethasone). Patients received either pregabalin 300 mg orally 1 h before surgery, dexamethasone 8 mg intravenously during induction, or placebo according to their allocation. Postoperative pain was treated with intravenous patient-controlled analgesia (tramadol, 20-mg bolus dose, 45-min lockout time). The numeric rating scale (NRS), side effects, and consumption of tramadol, pethidine, and ondansetron were assessed. The median NRS scores at 0, 1, and 6 h after surgery were significantly higher in Group C than in Group PD (p < 0.001 for all). The 24-h consumption of tramadol and pethidine was significantly reduced in Groups P and PD compared to Group C (p < 0.01 and p < 0.01). The total tramadol consumption was decreased by 54.5 % in Group P and 81.9 % in Group PD compared to Group C (p < 0.001 for both). The incidence of nausea was higher in Group C than in Groups P and PD between the postoperative 0-2 and 0-24-h periods (p < 0.05 for both). The frequency of blurred vision was significantly higher in Groups P and PD than in Group C within the 0-24-h period (p < 0.05 for both). We found that the addition of a single dose of pregabalin and dexamethasone to multimodal analgesia in rhinoplasty surgeries provided efficient analgesia and thus decreased opioid consumption. This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266.en_US
dc.identifier.doi10.1007/s00266-013-0207-0
dc.identifier.endpage1106en_US
dc.identifier.issn0364-216X
dc.identifier.issn1432-5241
dc.identifier.issue6en_US
dc.identifier.pmid24057811en_US
dc.identifier.scopus2-s2.0-84888184467en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage1100en_US
dc.identifier.urihttps://doi.org/10.1007/s00266-013-0207-0
dc.identifier.urihttps://hdl.handle.net/20.500.12491/7385
dc.identifier.volume37en_US
dc.identifier.wosWOS:000326890700003en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorBayır, Hakan
dc.institutionauthorDemirhan, Abdullah
dc.institutionauthorTekelioğlu, Ümit Yaşar
dc.institutionauthorAkkaya, Akcan
dc.institutionauthorBilgi, Murat
dc.institutionauthorApuhan, Tayfun
dc.institutionauthorKarabekmez, Furkan Erol
dc.institutionauthorKurt, Adem Deniz
dc.institutionauthorKoçoğlu, Hasan
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofAesthetic Plastic Surgeryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectPregabalinen_US
dc.subjectRhinoplastyen_US
dc.subjectPostoperative Painen_US
dc.titleEffect of pregabalin and dexamethasone addition to multimodal analgesia on postoperative analgesia following rhinoplasty surgeryen_US
dc.typeArticleen_US

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
Küçük Resim Yok
İsim:
abdullah-demirhan.pdf
Boyut:
274.83 KB
Biçim:
Adobe Portable Document Format
Açıklama:
Tam metin/Full text
İndir

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
Cerrahi Tıp Bilimleri Bölümü Koleksiyonu
PubMed İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu