The relationship of cognitive impairment with neurological and psychiatric variables in multiple sclerosis patients

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dc.authorid0000-0002-1422-1600en_US
dc.authorid0000-0003-1383-3557
dc.authorid0000-0001-6541-0666
dc.contributor.authorKaradayı, Hüsna
dc.contributor.authorArısoy, Özden
dc.contributor.authorAltunrende, Burcu
dc.contributor.authorBoztaş, Mehmet Hamid
dc.contributor.authorSercan, Mustafa
dc.date.accessioned2021-06-23T19:36:54Z
dc.date.available2021-06-23T19:36:54Z
dc.date.issued2014
dc.departmentBAİBÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.description.abstractObjective. Cognitive impairment (CI) in multiple sclerosis (MS) can develop any time. CI is associated with the degree of neuronal loss, but disease duration, fatigue, comorbid affective disorder, and drug dose may also affect cognition. Our aim was to assess which cognitive domain was disturbed primarily in mild MS patients and to see whether CI was related with clinical and psychiatric features. Method. Neurological and psychiatric evaluation of 31 MS patients and 31 age, sex, and education-matched healthy controls were made with Structured Clinical Interview for Axis I Disorders (SCID-I). Depression, anxiety, functionality, fatigue, and disability scoring were determined with Hamilton Depression-Anxiety scales, Global Assessment of Functionality, Fatigue Severity and Expanded Disability Status Scales. Cognitive functions were assessed using Mini Mental, Serial Digit Learning, Verbal and Nonverbal Cancellation, Stroop and Rey Auditory Verbal Learning tests. Results. Retrieval from long-term memory and psychomotor speed were significantly worse in MS group. CI was correlated with disease duration, number of attacks, and physical disability but not with depression and anxiety severity. Disease duration predicted disturbances in recall and psychomotor speed, whereas fatigue and disability predicted depression. Conclusion. Psychomotor speed and memory were primarily impaired in MS patients, and CI was closely associated with clinical aspects of MS rather than with depression and anxiety.en_US
dc.identifier.doi10.3109/13651501.2013.845221
dc.identifier.endpage51en_US
dc.identifier.issn1365-1501
dc.identifier.issn1471-1788
dc.identifier.issue1en_US
dc.identifier.pmid24047424en_US
dc.identifier.scopus2-s2.0-84894063012en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage45en_US
dc.identifier.urihttps://doi.org/10.3109/13651501.2013.845221
dc.identifier.urihttps://hdl.handle.net/20.500.12491/8075
dc.identifier.volume18en_US
dc.identifier.wosWOS:000331830900010en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorArısoy, Özden
dc.institutionauthorBoztaş, Mehmet Hamid
dc.institutionauthorSercan, Mustafa
dc.language.isoenen_US
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofInternational Journal Of Psychiatry In Clinical Practiceen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectMultiple Sclerosisen_US
dc.subjectCognitive Impairmenten_US
dc.subjectDepressionen_US
dc.subjectAnxietyen_US
dc.subjectDisabilityen_US
dc.titleThe relationship of cognitive impairment with neurological and psychiatric variables in multiple sclerosis patientsen_US
dc.typeArticleen_US

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