Genetic investigation of the trail mechanism in diabetic and non-diabetic obese patients

Basit Öğe Kaydı
dc.authorid0000-0002-8338-9546
dc.authorid0000-0003-2433-0277
dc.authorid0000-0001-6741-4345
dc.authorid0000-0003-3815-7444
dc.authorid0000-0003-2615-0202
dc.authorid0000-0001-5824-6159
dc.contributor.authorSezgin, Saadet Büşra Aksoyer
dc.contributor.authorDurak, Şermin
dc.contributor.authorÇelik, Faruk
dc.contributor.authorGheybi, Arezoo
dc.contributor.authorDıramalı, Murat
dc.contributor.authorÇakmak, Ramazan
dc.contributor.authorGürol, Ali Osman
dc.date.accessioned2024-09-25T19:59:00Z
dc.date.available2024-09-25T19:59:00Z
dc.date.issued2024
dc.departmentBAİBÜ, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü en_US
dc.description.abstractObesity is an important healthcare issue caused by abnormally increased adipose tissue because of energy-intake overcoming energy expenditure. Disturbances in the physiological function of adipose tissue mediate the development of diabetes. It is a metabolic disease that results from decreased insulin-levels and/or changes in the insulin action mechanism. Tumor Necrosis Factor-Associated Apoptosis-Inducing Ligand(TRAIL), which is a member of the Tumor Necrosis Factor(TNF)-family with an important role in adipose tissue biology, is included in many studies with its ability to induce apoptosis in cancer cells, but the number of human-studies conducted on the gene related to its protective-role against diabetes and obesity at this level is insufficient. Our study was carried out as a case and control and included three groups (80 diabetic obese, 80 non-diabetic obese, and 80 healthy individuals as the control group). The Real-Time-PZR(RT-qPZR), and DNA Sanger-Sequencing Methods were used for gene expression and gene squences. As a result of the analyses, TRAIL gene expression level was found to be higher in the controls than in the diabetic-obese and non-diabetic-obese group. This change in TRAIL gene expression suggests that TRAIL maybe a protective factor against diabetes. The presence of rs781673405, rs143353036, rs1244378045, rs767450259, rs759369504, rs750556128, and rs369143448 mutations, which was determined with the Sequencing-Method, was shown for the first time in the present study. In addition, it is the first study in which human TRAIL gene-expression and sequencing were performed together. We believe that these data will make an important contribution to the literature.en_US
dc.description.sponsorshipIstanbul University Scientific Research Projects Uniten_US
dc.identifier.doi10.1007/s10528-023-10624-1
dc.identifier.issn0006-2928
dc.identifier.issn1573-4927
dc.identifier.pmid38243005en_US
dc.identifier.scopus2-s2.0-85182667272en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttps://doi.org/10.1007/s10528-023-10624-1
dc.identifier.urihttps://hdl.handle.net/20.500.12491/13870
dc.identifier.wosWOS:001145705600003en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorDıramalı, Murat
dc.institutionauthorid0000-0001-5824-6159
dc.language.isoenen_US
dc.publisherSpringer/Plenum Publishersen_US
dc.relation.ispartofBiochemical Geneticsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.snmzYK_20240925en_US
dc.subjectObesityen_US
dc.subjectDiabetesen_US
dc.subjectTRAILen_US
dc.subjectExpressionen_US
dc.subjectSanger sequencingen_US
dc.titleGenetic investigation of the trail mechanism in diabetic and non-diabetic obese patientsen_US
dc.typeArticleen_US

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
Küçük Resim
İsim:
saadet-busra-sezgin.pdf
Boyut:
647.58 KB
Biçim:
Adobe Portable Document Format
Açıklama:
Tam metin/Full text
İndir

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu
Temel Tıp Bilimleri Bölümü Koleksiyonu