The acromegaly registry of ten different centers in Turkey

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dc.authorid0000-0003-2606-1103en_US
dc.authorid0000-0001-7357-8709en_US
dc.authorid0000-0002-4718-0083en_US
dc.contributor.authorKeskin, Çağlar
dc.contributor.authorDemir, Özgür
dc.contributor.authorKarcı, Alper Çağrı
dc.contributor.authorBerker, Dilek
dc.contributor.authorCantürk, Zeynep
dc.contributor.authorYaylalı, Güzin Fidan
dc.contributor.authorTopsakal, Şenay
dc.contributor.authorDilekçi, Esra Nur Ademoğlu
dc.date.accessioned2021-06-23T19:54:00Z
dc.date.available2021-06-23T19:54:00Z
dc.date.issued2020
dc.departmentBAİBÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.description.abstractObjectives: To describe biochemical and clinical features, and therapeutic outcomes of acromegaly patients in Turkey. Methods: Retrospective multicenter epidemiological study of 547 patients followed in 10 centers of the Turkish Acromegaly registry. Results: A total of 547 acromegaly patients (55% female) with a median age of 41 was included in this study. Majority of patients had a macroadenoma (78%). Transsphenoidal surgery was performed as primary treatment in 92% of the patients (n = 503). Surgical remission rate was 39% (197/503) in all operated patients. Overall disease control was achieved in 70% of patients. Remission group were significantly older than non-remission group (p = .002). Patients with microadenomas had significantly higher remission rates than patients with macroadenomas (p < .001). Patients with microadenomas were significantly older at the time of diagnosis when compared to patients with macroadenomas (p < .001). Preoperative growth hormone (GH) and insulin-like growth factor 1 (IGF-1) levels were significantly lower in the remission group (p < .001). Initial IGF-1 and GH levels were significantly higher in macroadenomas compared to microadenomas (p < .001). Medical treatment was administered as a second-line treatment (97%) in almost all patients without remission. Radiotherapy was preferred in 21% of the patients mostly as a third line treatment. Conclusions: This is one of the largest real life studies evaluating the epidemiological characteristics and treatment outcomes of patients with acromegaly who were followed in different centers in Turkey. Transsphenoidal surgery in the treatment of acromegaly still remains the most valid method. Medical treatment options may improve long-term disease outcomes in patients who cannot be controlled with surgical treatment (up to 70%).en_US
dc.identifier.doi10.1016/j.ghir.2020.101322
dc.identifier.issn1096-6374
dc.identifier.issn1532-2238
dc.identifier.pmid32417639en_US
dc.identifier.scopus2-s2.0-85084464699en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.urihttps://doi.org/10.1016/j.ghir.2020.101322
dc.identifier.urihttps://hdl.handle.net/20.500.12491/10376
dc.identifier.volume53-54en_US
dc.identifier.wosWOS:000574987700011en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorDilekçi, Esra Nur Ademoğlu
dc.language.isoenen_US
dc.publisherChurchill Livingstoneen_US
dc.relation.ispartofGrowth Hormone & Igf Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAcromegaly Registryen_US
dc.titleThe acromegaly registry of ten different centers in Turkeyen_US
dc.typeArticleen_US

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