Protective effect of edaravone against radiation-induced ovarian injury: a histopathological and immunohistochemical evaluation in an experimental rat model

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dc.authorid0000-0002-9617-6689en_US
dc.authorid0000-0002-2176-7863
dc.authorid0000-0002-4050-3193
dc.contributor.authorUral, Ülkü Mete
dc.contributor.authorGürlek, Beril
dc.contributor.authorAlver, Ahmet
dc.date.accessioned2021-06-23T19:17:08Z
dc.date.available2021-06-23T19:17:08Z
dc.date.issued2020
dc.departmentBAİBÜ, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümüen_US
dc.description.abstractPurpose We aimed to evaluate the protective effect of edaravone on radiation-induced ovarian damage in an experimental rat model. Methods Thirty-two Wistar albino female rats were randomly divided into four groups. Group 1: control, no treatment, and radiation was applied throughout the study; Group 2: sham, only radiation was applied; Group 3: 45 mg/kg edaravone and radiation were applied; Group 4: 450 mg/kg edaravone and radiation were applied. Edaravone was administered intraperitoneally 30 min before radiotherapy (5 Gy). Two days after radiation exposure, the rats were sacrificed and the ovaries were removed. Histologic changes under light microscopy and immunoreactivity for anti-caspase-3 were noted and compared between the four groups. Results There was a statistically significant difference in follicle counts, vascular congestion, edema, cytoplasmic vacuolization, hemorrhage, and interstitial cell degeneration between the groups. Radiation causes deterioration in most histopathological parameters. Administration of edaravone at different doses seems to reverse these alterations and alleviate the injury. Antioxidant defense mechanisms appear to be enhanced by edaravone as shown by histopathologically and decreased apoptosis by reducing the expression of anti-caspase-3 activity as demonstrated immunohistochemically. Conclusion This is the first study evaluating the protective effects of edaravone on radiation-induced ovarian damage. Edaravone decreased the follicular apoptosis and attenuates the radiation-induced ovarian damage in rats.en_US
dc.identifier.doi10.1007/s00404-020-05888-6
dc.identifier.endpage1016
dc.identifier.issn0932-0067
dc.identifier.issue4
dc.identifier.pmid33201374en_US
dc.identifier.scopus2-s2.0-85096125714en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage1009
dc.identifier.urihttps://doi.org/10.1007/s00404-020-05888-6
dc.identifier.urihttps://hdl.handle.net/20.500.12491/5242
dc.identifier.volume303
dc.identifier.wosWOS:000590209200001en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorUral, Ülkü Mete
dc.language.isoenen_US
dc.publisherSpringer Heidelbergen_US
dc.relation.ispartofArchives Of Gynecology And Obstetricsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectEdaravoneen_US
dc.subjectRadiationen_US
dc.subjectRaten_US
dc.subjectOvaryen_US
dc.titleProtective effect of edaravone against radiation-induced ovarian injury: a histopathological and immunohistochemical evaluation in an experimental rat modelen_US
dc.typeArticleen_US

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